Those E2's think they're so cool. . . not so fast!

[broiler_x]

https://www.ncbi.nlm.nih.gov/pubmed/31485353

Apolipoprotein E2 Genotype Is Associated with a 2-Fold Increase in the Incidence of Type 2 Diabetes Mellitus: Results from a Long-Term Observational Study

[Julie G]

I believe this. My husband is a 2/3 and generally lives like most of us. His last hbA1c was 5.6 vs. my 4.7. Sigh.

[Emerald]

There are downsides associated with all forms of APOE.

A recent study indicated that APOE 2/4 people may not really benefit from much Alzheimer's protection, as APOE4 much more strongly overrides the benefits of APOE2 than it overrides APOE3. I'll have to dig up the study.

[hairyfairy]

I read in a recent article, I think that it was pub med, that apoe2 is also associated with an increased risk of neck fractures.