Markers associated with genetic resililience to AD in E4/E4's
Posted: Thu Sep 12, 2019 12:45 pm
https://www.ncbi.nlm.nih.gov/pubmed/31506248
These guys did a study to look at just E4/E4's over the age of 75 who have not developed AD and looked at their genome SNP's to see if any genetic markers were associated with the resilience to developing AD. They found 2 SNP's that seemed to have "strong evidence" for resilience (CASP7 rs10553596 and SERPINA3 rs4934-A/A). I just checked my 23andme genome data to see if I have either of those SNP's and saw that I had rs4934-A/A. It's possible that 23andme doesn't even check for the other SNP (not sure how to check for that).
Keep in mind that this is correlation and not causation and all the caveats associated with that. And this is a single study, and genes are not destiny etc., etc.
These guys did a study to look at just E4/E4's over the age of 75 who have not developed AD and looked at their genome SNP's to see if any genetic markers were associated with the resilience to developing AD. They found 2 SNP's that seemed to have "strong evidence" for resilience (CASP7 rs10553596 and SERPINA3 rs4934-A/A). I just checked my 23andme genome data to see if I have either of those SNP's and saw that I had rs4934-A/A. It's possible that 23andme doesn't even check for the other SNP (not sure how to check for that).
Keep in mind that this is correlation and not causation and all the caveats associated with that. And this is a single study, and genes are not destiny etc., etc.