In the study, published Nov. 6 in the journal Aging Cell, researchers began rats on a diet including low-dose rapamycin at 19 months old (past middle age in rat years). Rapamycin treatment in daily food continued until the mice were of advanced age -- 34 months old -- almost double the age they were when they started treatment. "Essentially this is as old as these rats can get. These animals were very old but still, blood circulation in the brain was exactly the same as when they started treatment," said study senior author Veronica Galvan
For those of you who like the hard stuff, here's the actual [open access] paper:
mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging
Candice E. Van Skike, Ai‐Ling Lin, Raquel Roberts Burbank, Jonathan J. Halloran, Stephen F. Hernandez, James Cuvillier, Vanessa Y. Soto, Stacy A. Hussong, Jordan B. Jahrling, Martin A. Javors, Matthew J. Hart, Kathleen E. Fischer, Steven N. Austad, Veronica Galvan.
Aging Cell, 2019; DOI: 10.1111/acel.13057
Obligatory disclaimer: Rats and humans differ.