Thanks for posting this, sarahB12. I'm FASCINATED and think this mechanistically tells us something very important. Clearly activating the immune system is key, but why TB bacteria through the bladder?
Also, some medicines used to treat TB, methylene blue and artemisinin, seem to show action against AD. Oddly, these are also used for malaria - maybe because they are both at least somewhat antibiotic?
Interesting hypothesis. I had a severe case of babesia duncani (very similar to malaria) for 15 years. I'll cross my fingers that my treatment has reduced my chance of developing AD.
So, does that mean we should get a BCG vaccine, if possible? I read that the vaccine is not recommended for general use in the U.S.
From what I'm reading, as Family Tree Guy alludes, multiple vaccinations were injected into the bladder. We don't know that standard TB vaccines will also reduce risk. I spent a few hours in a rabbit hole trying to determine if countries (where the vaccine is still required) have lower rates of AD. From my rudimentary probing around, it appears that may be the case, but we need researchers to dive into this angle so that we can better understand. Countries that still require a TB vaccine are also much less modernized which may be a risk factor in and of itself...