NAD+ homeostasis in health and disease

[BrianR]

Very detailed review of NAD+ for those who want to better understand this molecule. Open access at the URL, not sure if it's time limited. (The site discourages downloading of the open access version.)

The conceptual evolution of nicotinamide adenine dinucleotide (NAD+) from being seen as a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and longevity, including the sirtuin family of protein deacylases, has led to a new wave of scientific interest in NAD+. NAD+ levels decline during ageing, and alterations in NAD+ homeostasis can be found in virtually all age-related diseases, including neurodegeneration, diabetes and cancer. In preclinical settings, various strategies to increase NAD+ levels have shown beneficial effects, thus starting a competitive race to discover marketable NAD+ boosters to improve healthspan and lifespan. Here, we review the basics of NAD+ biochemistry and metabolism, and its roles in health and disease, and we discuss current challenges and the future translational potential of NAD+ research.

https://www.nature.com/articles/s42255- ... 8j1A%3D%3D

NAD+ homeostasis in health and disease
Elena Katsyuba, Mario Romani, Dina Hofer & Johan Auwerx
Nature Metabolism (2020). Published 20 January 2020.
DOI: 10.1038/s42255-019-0161-5

NAD+ Fig 4.png