Welcome to the APoE4 community Mags. Thank you for sharing the research articles. It is encouraging to see research being done concerning the ApoE4 gene. I'd like to share with you a few tips you will find helpful as a new user to the website. The Primer is a good place to get started. It was brilliantly written by a member physician with the ApoE4 gene. Another handy resource is the Main Wiki page. You will find all kinds of key materials. If you would like to share more about yourself and what brought you to this community, you may tell your story here. There are so many places to explore on this website and plenty of wonderful members who are ready to support you! Glad you have joined us.Mags wrote:https://www.theguardian.com/world/2020/may/26/research-reveals-gene-role-in-both-dementia-and-severe-covid-19
Ergodoy wrote:It sounds like there is an increased risk of severe disease per a study published May 26 in however I am a little unsure of whether the data has a significant cohort of 4/4 with COVID-19
The cohort is taken from 451,367 individuals participating in UK assessment centers. 9,022 were found to be 4/4.
622 of the entire cohort later ended upCOVID positive with only 37 of these were 4/4.
Confounders such as DM, dementia and CAD were excluded. However, I would take this as a preliminary finding with more investigation needed.
Here is their conclusion: Further investigation is needed to understand the biological mechanisms linking ApoE genotypes to COVID-19 severity.”
https://academic.oup.com/biomedgerontol ... laa131.pdf
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