New pilot study showing favorable effects of modified mediterranean ketogenic diet
Posted: Mon Feb 17, 2020 10:29 am
Modified ketogenic diet is associated with improved cerebrospinal fluid biomarker profile, cerebral perfusion, and cerebral ketone body uptake in older adults at risk for Alzheimer’s disease [Pilot; n=20]
This is the first I've heard of an '11C-acetoacetate PET' to measure ketone uptake, but I'm sure it's not the first it's been used.All participants had improved metabolic indices following MMKD. MMKD was associated with increased cerebrospinal fluid Aβ42 and decreased tau. There was increased cerebral perfusion and increased cerebral ketone body uptake (11C-acetoacetate PET, in subsample) following MMKD. Memory performance improved after both diets, which may be due to practice effects. Our results suggest that a ketogenic intervention targeted toward adults at risk for Alzheimer’s may prove beneficial in the prevention of cognitive decline.