When I clicked the link at the end of the article to see details it went to a dead-end page.
Julie G wrote:Might imply something about the amyloid hypothesis? Instead of "doubling down," it might be time to look up and expand mainstream thinking on how to treat this multifactorial disease process.
Hi jmac,Jmac wrote:Julie G wrote:Might imply something about the amyloid hypothesis? Instead of "doubling down," it might be time to look up and expand mainstream thinking on how to treat this multifactorial disease process.
I have a variety of Google alerts set up on AD, dementia, studies, etc. I am amazed at how they keep going after the same "causes" and trying again and again for drugs to treat the same ol', same ol'. Sooner of later they'll catch up with us
* Access to secure, personalized, web-based tools to assess and track your cognitive performance
* Opportunity to participate in comprehensive evaluations at one of our nationwide clinical sites
* Opportunity to participate in clinical trials to prevent Alzheimer’s disease
APT Webstudy participants take online memory tests every three months, which take about 20 minutes to complete.
To enroll, registration takes about 30 minutes. This first visit will also ask you to agree/consent to participate, and to complete both the Cognitive Function Index (CFI) survey and the Cogstate memory assessment.
If we notice any changes in your memory and thinking performance overtime, we may invite you to a clinic located closest to you for further evaluation. Based upon this, you may then be matched to an Alzheimer's prevention trial if you are eligible.
https://www.actcinfo.org/submit-a-proposal/Anyone is eligible. Non-pharamacological interventions are encouraged. ACTC works in collaboration with proposers to develop the project idea and submit grant for funding. Project ideas can include Alzheimer's disease as well as other related disorders.
Full disclosure: I recently participated in a newly-formed Alzheimer's Research Participant Advisory Board composed of 10 people (and some of their spouses) who have participated in a variety of clinical trials, or been screened and declined to participate, or cared for someone with early-onset AD, late-onset AD or dominantly-inherited AD.
As an explanation of why they persist: research shows that people with elevated amyloid beta show no functional or cognitive impairment at baseline, but their risk of accelerated progression to SCI and MCI over 6-10 years is statistically higher than similar people (including ApoE 4) without elevated levels. Some research suggests this is even more true for ApoE 4 carriers. No one antibiotic kills all bacteria; by analogy they hope to be part of finding the "antibiotic" that at least slows their risk of AD and shows what happens over time to people with elevated amyloid if they do everything else right with lifestyle and supplements (none of that precludes their participation). I support their decision completely, and think we all have to recognize their choice is as valid as our own decisions.
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