Hi Jacque,Jaque wrote:Dr. Nadir Mir Ali claims most APOE4 people are smarter than APOE3 or 2 people! See this new video -
I enjoyed Dr. Ali's explanations, and while some of the science can be technical, he does a great job of explaining it." He doesn't mention IQ until about 22:00 minutes into this 31 minute video and "trigger alert", he also uses a slide that people who like President Trump will find offensive (and apologizes for it in his comments on YouTube). He does mention some evidence that ApoE4 brains may absorb produce more cholesterol in both the liver and the brain, and in the brain that may keep neurons healthy and contribute to some studies finding higher levels of verbal intelligence in people with Apoe4. He does acknowledge that cholesterol has been "stigmatized, so nobody studies cholesterol in the brain", so we don't really know if this is true. But it's nice to have something good to claim for ourselves!Cerebral Insulin resistance is a primary driver of dementia. This leads to reduced glucose utilization by the brain. Apo4 can potentially worsen brain insulin resistance, with is worsened by the Standard American Diet. The presentation is about how high insulin levels down-regulates insulin receptor contributing to cerebral insulin resistance & leading to accumulation of amyloid beta in the brain.
Jaque wrote:Dr. Nadir Mir Ali claims most APOE4 people are smarter than APOE3 or 2 people! See this new video -
NF52 wrote:I think this talk was from the Low Carb conference just last week in Denver, since it was posted March 17, so I'll copy Theresa B and Tincup, two of our Moderators, who I think attended that conference and may want to share their perspective on this timely post
Jaque wrote:Re: "cyclically activating our insulin receptors"
In his another talk on "intermittent fasting" he claims that fasting achieves that with appropriate foods.
Overall, full-scale IQ scores were lower by 1.91 points for each APOE4 allele an individual carried. A person can have up to two APOE4 alleles, and the gene's effect on IQ performance multiplies with each allele present. Boys scored .33 points lower on IQ tests, and girls scored almost 3 points lower for each APOE4 allele. The traits most affected related to reasoning.
The IQ difference seems small. But long-term, Reynolds said the findings can mean reduced cognitive reserve as the APOE4 carrier ages, with the disadvantage becoming progressively magnified. Cognitive reserve is the brain’s ability to navigate problems and improvise. Cognitive reserve theory holds that people with reduced reserve have more trouble withstanding disease as they age.
Research has also shown an association between lower childhood IQ and increased biological aging—cell and tissue damage—and cardiovascular disease before age 65.
“Our results suggest that cognitive differences associated with APOE may emerge early and become magnified later in the life course, and if so, childhood represents a key period of intervention to invest in and boost reserves,” Reynolds wrote in the paper, titled “APOE effects on cognition from childhood to adolescence
https://news.ucr.edu/articles/2019/07/1 ... -adulthood
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