Extensive review: mTOR at the nexus of nutrition, growth, ageing and disease
Posted: Thu Mar 26, 2020 5:02 pm
For those who are particularly interested in understanding the mTOR pathway, this open access version of a Nature Reviews article should be quite useful.
https://www.nature.com/articles/s41580- ... ROfg%3D%3D
mTOR at the nexus of nutrition, growth, ageing and disease
Grace Y. Liu and David M. Sabatini
Abstract | The mTOR pathway integrates a diverse set of environmental cues, such as growth factor signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half decades, mapping of the mTOR signalling landscape has revealed that mTOR controls biomass accumulation and metabolism by modulating key cellular processes, including protein synthesis and autophagy. Given the pathway’s central role in maintaining cellular and physiological homeostasis, dysregulation of mTOR signalling has been implicated in metabolic disorders, neurodegeneration, cancer and ageing. In this Review, we highlight recent advances in our understanding of the complex regulation of the mTOR pathway and discuss its function in the context of physiology, human disease and pharmacological intervention.
281 references!
https://www.nature.com/articles/s41580- ... ROfg%3D%3D
mTOR at the nexus of nutrition, growth, ageing and disease
Grace Y. Liu and David M. Sabatini
Abstract | The mTOR pathway integrates a diverse set of environmental cues, such as growth factor signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half decades, mapping of the mTOR signalling landscape has revealed that mTOR controls biomass accumulation and metabolism by modulating key cellular processes, including protein synthesis and autophagy. Given the pathway’s central role in maintaining cellular and physiological homeostasis, dysregulation of mTOR signalling has been implicated in metabolic disorders, neurodegeneration, cancer and ageing. In this Review, we highlight recent advances in our understanding of the complex regulation of the mTOR pathway and discuss its function in the context of physiology, human disease and pharmacological intervention.
281 references!