Blood clotting and Alzheimer's

[Julie G]

A recent study from the Gladstone Institutes finds that fibrinogen, a key blood coagulation component, is involved in a cascade of events at both molecular and cellular events which lead to Alzheimer’s. Read about the possible link with both the amyloid and vascular hypotheses (also helps to explain cerebral amyloid angiopathy) in this press release. I’m struck by the overlap with Covid-19, in which inflammation also appears to thicken the blood and to which E4 carriers may be more susceptible. While anticoagulant therapy is tricky in the elderly, it seems like maintaining an optimal omega-3 index, >10% would certainly be helpful (to both reduce inflammation and optimize blood viscosity) with a good omega 6:3 ratio, better than 4:1.

[healing]

New to site. Regarding 6:3 ratio - how to determine this? For example, put walnuts in smoothie and need help here, period.

Also, since tending to be a loner, not good says Primer writings, what tests to take as unknowning not good.

Thx

[Tincup]

New to site. Regarding 6:3 ratio - how to determine this? For example, put walnuts in smoothie and need help here, period.

Also, since tending to be a loner, not good says Primer writings, what tests to take as unknowning not good.

Thx

We routinely have our omega-3 index tested.

Mainly, we don't seed oils and we do consume a fair amount of fish oils.

[healing]

Hi Tincup
We don't seed - do you mean need oils?

Testing, good.

How to assess brain, now. If forget to take brain suppement, noticing and wondering what tests to take? I don't want disease, herewith.

[Tincup]

Hi Tincup
We don't seed - do you mean need oils?

How to assess brain, now. If forget to take brain suppement, noticing and wondering what tests to take? I don't want disease, herewith.

I meant we don't eat seed oils, like Soy, Grapeseed, Corn, Cottonseed, Safflower, Sunflower, “Partially Hydrogenated, “Vegetable” Oils, Canola.

I've not done brain test, so can't comment there.

[TheresaB]

New to site. Regarding 6:3 ratio - how to determine this? For example, put walnuts in smoothie and need help here, period.

Welcome Healing. We have a wiki article on Omega -3s and Omega -6s: Fats, Omega -3(ω-3) & -6(ω-6), DHA and More https://www.apoe4.info/wiki/Fats,_Omega ... A_and_More

In the write up there is a discussion on the Omega 6 to Omega 3 ratio, with strategies on how to improve it along with rationale as to why this is important.

wiki.jpg

[SusanJ]

Here's an article from 2018 that goes into detail about how fibrinogen works, and interacts with immune cells in the brain, including sections about MS and AD specifically. Also tied directly to a healthy BBB because fibrinogen is created in the liver, and crosses a leaky BBB to start a cascade of events including interactions with amyloid.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743980/

[SusanJ]

And because fibrinogen is linked to inflammation, it looks like keeping iL-6 low is important, too, because it induces the expression of fibrinogen.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669433/ (from 2017)

[Julie G]

And because fibrinogen is linked to inflammation, it looks like keeping iL-6 low is important, too, because it induces the expression of fibrinogen.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669433/ (from 2017)

Good sleuthing, Susan. All of the things that we regularly do to keep inflammation low appear to be foundational for multiple mechanisms.

[SusanJ]

And the news today that dexamethasone can save lives in seriously ill Covid-19 patients just reinforces this, because dexamethasone reduces iL-6 (interleukin-6), which as mentioned above, reduces fibrinogen production.

https://www.reuters.com/article/us-heal ... SKBN23N1VP

Minding our strategies for reducing fibrinogens is starting to feel very important at this point for us E4s. Self-hacked has an article on it at: https://selfhacked.com/blog/high-fibrinogen/. Many of the strategies are well-known in this community.