SusanJ wrote:I read about this yesterday and found the HDL and apoC3 level connection interesting.
Here's .... their earlier work on the apoE, HDL and apoC3 connection.
aphorist wrote:I'm sure you already know about the Krauss paper (Faghihina, Krauss 2012) indicating a high SFA diet leads to higher ApoC3 content in LDL particles vs. a lower SFA diet.
SusanJ wrote:Missed that one. Thanks for the reference. Saturated fat does bad things to my lipids, so I'm definitely interested in reading that.
In the setting of moderate carbohydrate intake, HSF vs. LSF intake significantly increased LDL total mass concentration by 15.2% as well as LDL apoCIII content by 33.5% (Table 5). The change in LDL mass was attributable to significant increases in the mass concentrations of LDL subclasses I, II and III by 19.0, 20.1 and 16.5%, respectively, but was significantly correlated only with changes in LDL III (r = 0.65, P = 0.01) (data not shown). The relative enrichment of apoCIII per apoB in total LDL tended to increase with HSF vs. LSF intake (P = 0.07) (data not shown).
“The findings by Koch et al1 therefore raise the possibility that composition of the HDL-associated proteome may be a key determinant of apoE-associated risk of AD and all-cause dementia. Identifying HDL-associated protein cargo and apoE-interacting proteins in HDL fractions may hence provide further insights into the role of APOE in AD pathogenesis.“
I'm sure you already know about the Krauss paper (Faghihina, Krauss 2012) indicating a high SFA diet leads to higher ApoC3 content in LDL particles vs. a lower SFA diet...It seemed to indicate that a diet higher in DHA content (this is in pigs, mind you) lowered ApoC3 activity.
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