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apoe4 carries can diminish their dementia risk by reducing their cv risk

Insights and discussion from the cutting edge with reference to journal articles and other research papers.
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apoe4 carries can diminish their dementia risk by reducing their cv risk

Postby Stefan » Mon Jul 27, 2020 9:14 am

A new Boston University School of Public Health (BUSPH) and School of Medicine (BUSM) study finds that genes and cardiovascular health can both raise or lower risk of dementia, Neurology, [url]DOI: 10.1212/WNL.0000000000010306[/url]
"Previous research has suggested that cardiovascular health affects a person's risk of dementia and Alzheimer's. For this study, the researchers scored participants on the American Heart Association's seven components of cardiovascular health: physical activity, cholesterol, healthy diet, blood pressure, weight, blood glucose, and smoking status. They found that participants with a favorable cardiovascular health score were 55% less likely to develop dementia than participants with an unfavorable score"
Actually not new, as we know that we have to work on our cv health in order to lower our dementia risk. Now it is proven.....

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Re: apoe4 carries can diminish their dementia risk by reducing their cv risk

Postby circular » Tue Jul 28, 2020 12:49 pm

Thanks Stefan. I've been starting to keep track of interventions with a large effect size, because it's quite possible that some don't need to over-worry the more nuanced details if they get all the broad strokes right. In the least, interventions with a large effect are probably the best place for people to start who are new to brain healthy lifestyle changes. I think we can do even more to optimize brain health, but these kinds of standard recommendations can significantly transform risk for so many.

Here's a working link to the abstract, from where the .pdf is available.

Here's a link to the ScienceDaily article 'Genes and cardiovascular health both affect dementia risk]Genes and cardiovascular health both affect dementia risk'.

It may be important to note that ApoE4 and CVD risk were additive, independent risk factors.
We did not observe an interaction between CVH [cardiovascular health] and GRS [genetic risk score] (p=0.99) or APOE e4 (p=0.16)

They also give a little more detail about the ideal CVD parameters yielding the benefit:
Ideal CVH score was calculated by summing together 7 optimal levels of CVH according to to the AHA guidelines at exam 5. One point was added for each of the following optimal levels of the CVH score components: current self-reported nonsmoker, body mass indexes of <25 and >18.5 kg/m2, adequate physical activity, a healthy diet, untreated total cholesterol <200 mg/dL, untreated resting blood pressure <120/<80 mm Hg, and fasting blood glucose <100 mg/dL. All factors were obtained from the Framingham Heart Study clinic except diet and physical activity, which were measured with the use of a validated food frequency and physical activity index questionnaire, respectively. Physical activity was calculated using the following formula as per previous Framingham Heart Study publications 8, 19: 1*sleep hours/day + 1.1*sedentary hours/day + 1.5*slight activity hours/day + 2.4*moderate activity hours/day + 5*heavy activity hours/day. The top quartile of this score was used to indicate ideal physical activity, which corresponds qualitatively to the definition used by the AHA.17 Diet scores were adapted from the AHA guidelines 17, consistent with a previous Framingham Heart Study publication.8, 19 Blood pressures were measured twice at the same exam by a physician, with the averaged systolic and diastolic values used in the ideal CVH score.

I don't understand how the physical activity formula works. One should be in the upper quartile. Apparently I may not need to understand it because it corresponds to AHA exercise guidelines:
Recommendations for Adults

Get at least 150 minutes per week of moderate-intensity aerobic activity or 75 minutes per week of vigorous aerobic activity, or a combination of both, preferably spread throughout the week.
Add moderate- to high-intensity muscle-strengthening activity (such as resistance or weights) on at least 2 days per week.
Spend less time sitting. Even light-intensity activity can offset some of the risks of being sedentary.
Gain even more benefits by being active at least 300 minutes (5 hours) per week.
Increase amount and intensity gradually over time.

The diet standard also matched AHA diet guidelines:
Eat an overall healthy dietary pattern that emphasizes:

a variety of fruits and vegetables
whole grains
low-fat dairy products
skinless poultry and fish
nuts and legumes
non-tropical vegetable oils

Limit saturated fat, trans fat, sodium, red meat, sweets and sugar-sweetened beverages. If you choose to eat red meat, compare labels and select the leanest cuts available.

One of the diets that fits this pattern is the DASH (Dietary Approaches to Stop Hypertension) eating plan.

I find it interesting they didn't include an ideal LDL score. I wonder if it didn't matter as long as total cholesterol was <200 mg/dL.
ApoE 3/4 > Thanks in advance for any responses made to my posts.

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