Just published in JAMA are results from a large study examining a blood marker for early detection of Alzheimer Disease. The marker is P-tau217, and it appears to be elevated up to 20 years before any symptoms. Surprisingly, no mention of ApoE status of the participants. Here's the paper:
https://jamanetwork.com/journals/jama/f ... le/2768841
And if you want a simpler summary of the findings, read this:
https://www.fiercebiotech.com/medtech/a ... ly-warning