Wine and Cheese Might Actually Help You Avoid Dementia

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NewRon
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Wine and Cheese Might Actually Help You Avoid Dementia

Post by NewRon »

Apo E4/E4, Male, Age 60
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TheresaB
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Re: Wine and Cheese Might Actually Help You Avoid Dementia

Post by TheresaB »

Seems as though those are two things ApoE4s should avoid. Did the research stratify by ApoE status?
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BrianR
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Re: Wine and Cheese Might Actually Help You Avoid Dementia

Post by BrianR »

Genetic Factors of Alzheimer’s Disease Modulate How Diet is Associated with Long-Term Cognitive Trajectories: A UK Biobank Study

Behind a paywall, you'll need to use Sci-hub to look at it.

The study used retrospective food consumption questionnaires. Which, of course, are known to have issues.

APOE4 status was considered. E.g.:
Predictors of fluid intelligence by APOE4 status.png
They claim to have accounted for social-economic stratification, but didn't provide any data stratified by that factor. (Wealth or income can influence both wine & cheese consumption and dementia outcomes.) Also, I wonder if wine & cheese are more often consumed in the company of others, which I expect would improve dementia outcomes.

Overall, I just can't get very excited over results based on food questionnaires. I wouldn't be surprised if modest wine and cheese consumption, particularly in the context of meals consumed socially, would not be harmful for APOE4+. I could believe that additional non-carbohydrate calories consumed by non-obese seniors might improve outcomes.
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Nikki2019
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Re: Wine and Cheese Might Actually Help You Avoid Dementia

Post by Nikki2019 »

I just stumbled across this notion in yahoo news as I was scrolling to read about the latest with the Covid situation. It surprised me, because I have heard Gundry say to stay away from E4's favorite food, cheese. So I looked in this forum and see it has already been spoken for.

When I think of wine and cheese, I think of socializing with intellectuals over a game of chess. As opposed to chugging a beer at a frat party with a bunch of drunk bafoons. :lol:

To better understand if it is really the wine and cheese.. maybe bring that to the frat party and the beer to the chess game?
https://www.yahoo.com/lifestyle/wine-ch ... 00304.html
As E4 s, we are inherent fighters and don't give up so easily.
TLS
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Re: Wine and Cheese Might Actually Help You Avoid Dementia

Post by TLS »

I just listened to a podcast by Dementia Matters out of Wisconson (I know cheese state!) on this topic with Auriel Willette, PhD, associate professor of food science and human nutrition, Iowa State University. I found listening to the podcast to be helpful because then you can hear the nuances of the study. For me personally, I plan to include more Lamb. Note the sound quality is not great on Auriel's side.
  • Low salt - Our data supports that excess dietary salt intake appears to harm cognition, but we only noted this observation for individuals with the presence of FH (Family History) or APOE4.
  • Red wine - moderate consumption. Furthermore, we did observe a significant association between red wine and higher FI (Fluid Intelligence)in our data, but only in those with a APOE4− genotype or a family history of Alzheimer’s disease. Those who were APOE4+ or had no family history of Alzheimer’s disease, on the other hand, showed no such association.
  • Lamb - compared to beef, lamb meat may contain more than twice the amount of oleic fatty acid content, the type most prevalent in olive oil [54]. Lamb is also high in taurine, carnosine, coenzyme Q10, and creatine
  • Hard Cheese - We observed among E4−, E4+, and FH (Family History)− individuals that greater cheese consumption was associated with healthier cognitive trajectories; however, we did not observe associations between cheese and executive function among those who were FH+.
Podcast Link: https://www.adrc.wisc.edu/dementia-matt ... its-cheese
Study Link: https://www.research.iastate.edu/news/i ... e-decline/
Full Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895545/
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