I found this figure quite surprising. The Middle East has 8 of the top ten affected Alzheimer's nations in the world? See Above! Has this been age standardized? Some of these nations have embraced population scale genome sequencing. It would perhaps make a great deal of sense if they were to consider a pan-Middle Eastern AD full genome project. This has not been done anywhere in the world up till to scale. At ~~1 million genomes the genetic architecture of Alzheimer's unlock. It has to make sense to step forward with $300 million to do this. As many of those on forum recognize-- learning that you are epsilon 44 is not comforting, though living your life in ignorance of this would be worse. It would just pop out of nowhere one day and you would be totally unprepared. It is possible that the Middle East has their own variants that have not been found elsewhere. We also know that there is a substantial amount of AD genetics that have yet to have been found.
Israel (unsurprising given the substantial long term selection effects) and Kuwait are noted above for being low risk AD nations. The only notable high-risk nation from Europe was Finland. There were also quite a few high-risk nations noted in the Indo-China region including Indonesia, Cambodia, Thailand, etc., along with several low risk nations such as Singapore, Krygyzstan and The Philippines. Having a good epidemiological understanding could be helpful in developing clues about genetics, possible natural treatments etc..