Interaction between APOE ε4 and dietary protein intake on cognitive decline: A longitudinal cohort study
We observed significant interactions of APOE ε4 with DDPI [Diverse Dietary Protein Intake] and fish intake, at multiple correction-adjusted Ps < 0.05. In those who were APOE ε4 carriers rather than non-carriers, both high DDPI (OR = 0.54, 95% CI: 0.34–0.88) and daily fish intake (OR = 0.43, 95% CI: 0.22–0.78) were significantly associated with slower cognitive decline, respectively. We also found that frequent intake of fish benefits women more than men regarding the mitigating of cognitive decline among APOE ε4 allele carriers (P for interaction = 0.016).
When they say "...and daily fish intake...", do they mean that the Apo E4's in the study that ate only fish every day, had a slower cognitive decline, or does it mean that those people ate more fish in general, wrt the others in the study?
NewRon wrote:When they say "...and daily fish intake...", do they mean that the Apo E4's in the study that ate only fish every day, had a slower cognitive decline, or does it mean that those people ate more fish in general, wrt the others in the study?
I can't get to the full article to answer your question. SciHub doesn't seem to have access to it ATM.
That said, I read this as E4s who ate fish daily and also ate varied protein sources had better cognition.