Brain cell cleaning to reverse Alzheimer

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StevenL
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Brain cell cleaning to reverse Alzheimer

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Experimental-drug-boosts-brain-cell-cleaning-to-reverse-alzheimers-disease-symptoms-in-mice

https://www.genengnews.com/news/experim ... s-in-mice/
Cuervo and colleagues report on their work in Cell, in a paper titled, “Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.”
https://doi.org/10.1016/j.cell.2021.03.048

Saw this and want to make sure others have it on their radar.
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floramaria
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Re: Brain cell cleaning to reverse Alzheimer

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StevenL wrote:Experimental-drug-boosts-brain-cell-cleaning-to-reverse-alzheimers-disease-symptoms-in-mice

https://www.genengnews.com/news/experim ... s-in-mice/
Cuervo and colleagues report on their work in Cell, in a paper titled, “Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.”
https://doi.org/10.1016/j.cell.2021.03.048

Saw this and want to make sure others have it on their radar.
Hi StevenL, I got a chance to read this tonight. It is an interesting approach.
Thanks for posting it.
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StevenL
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Re: Brain cell cleaning to reverse Alzheimer

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Yes! From what I can understand, this is forcing or reinforcing the natural clearing mechanism that we get when we sleep? I have trouble getting enough good sleep, especially with chronic Lymes mixed with ageing.

So it's very interesting to think there may be something that can facilitate the same. Most of us would certainly prefer the most natural path to brain health but in a pinch, will accept any hammer that might hit the nail.

Just proving the value of autophagy as well showing some of the mechanisms that seem to be receptive to tweaking is of value. Hope it pans out.

They also seem to show an actual reversal effect. In mice.
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floramaria
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Re: Brain cell cleaning to reverse Alzheimer

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StevenL wrote: They also seem to show an actual reversal. In mice.
yeah, that “in mice” or “in fruit flies” is always disappointing. So many things have improved cognition in Mice but not done the same for humans. But I do trust that all of the studies, even when they don’t work in humans, help point the way to eventual success.
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