cholesterol and steroidogenesis pathways

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MadScientist
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cholesterol and steroidogenesis pathways

Postby MadScientist » Sat Aug 01, 2020 6:31 am

Hi,

If total cholesterol increases steadily over several years, and pregnenolone remains bottom of the barrel-low (along with other sex-hormones) what would be the location of the metabolic defect? Mitochondria? Adrenal issues? It appears that non-HDL cholesterol increased.

There are no ovaries, and hormone supplements have been used, though not perfectly. Only recently found a ReCode practitioner.

Thoughts?
ApoE 3/4, female, 58 yrs
MTHFR compound heterozygous

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Julie G
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Re: cholesterol and steroidogenesis pathways

Postby Julie G » Sun Aug 02, 2020 5:17 pm

How is your stress level? Cortisol is well known to interfere with hormone production.

circular
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Re: cholesterol and steroidogenesis pathways

Postby circular » Mon Aug 03, 2020 11:33 am

MadScientist wrote:Hi,

If total cholesterol increases steadily over several years, and pregnenolone remains bottom of the barrel-low (along with other sex-hormones) what would be the location of the metabolic defect? Mitochondria? Adrenal issues? It appears that non-HDL cholesterol increased.

There are no ovaries, and hormone supplements have been used, though not perfectly. Only recently found a ReCode practitioner.

Thoughts?

My thoughts, knowing nothing about this other than I also had bottom of the barrel pregnenolone (two in a row to verify), are to bring up the pregnenolone and then compare hormone levels as a really basic start. I didn't have baselines of my other hormones before and after supplementing pregnenolone, but my pregnenolone responded well to cheap 10 mg/day upon repeated repeat testing.
ApoE 3/4 > Thanks in advance for any responses made to my posts.


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