If total cholesterol increases steadily over several years, and pregnenolone remains bottom of the barrel-low (along with other sex-hormones) what would be the location of the metabolic defect? Mitochondria? Adrenal issues? It appears that non-HDL cholesterol increased.
There are no ovaries, and hormone supplements have been used, though not perfectly. Only recently found a ReCode practitioner.
My thoughts, knowing nothing about this other than I also had bottom of the barrel pregnenolone (two in a row to verify), are to bring up the pregnenolone and then compare hormone levels as a really basic start. I didn't have baselines of my other hormones before and after supplementing pregnenolone, but my pregnenolone responded well to cheap 10 mg/day upon repeated repeat testing.
ApoE 3/4 > Thanks in advance for any responses made to my posts.