I wonder how myeloperoxidase compares to LP-PLA2 testing. I tested LP-PLA2 last year and was found to be well within the normal range.
Earlier in this thread, I was writing about the high correlation of oxLDL and Lp(a) which for me has been mostly well above lab cutoffs. I found this paper ("Oxidized Phospholipids, Lp(a) Lipoprotein, and Coronary Artery Disease" N Engl J Med 2005;353:46-57) and was very interested to find this is the discussion:
This study shows an association between the oxidized
phospholipid:apo B-100 ratio in plasma and
the presence and extent of angiographically documented
coronary artery disease. The association is
independent of all clinical and lipid-related risk
factors, except one, Lp(a) lipoprotein, which also
has a strong association with angiographically documented
coronary artery disease. The odds ratios
for angiographically documented coronary artery
disease associated with the Lp(a) lipoprotein level
were nearly identical with those associated with the
oxidized phospholipid:apo B-100 ratio. However,
among patients younger than 60 years of age, the
oxidized phospholipid:apo B-100 ratio remained
an independent predictor of obstructive coronary
artery disease. There was a strong correlation between
levels of Lp(a) lipoprotein and the oxidized
phospholipid:apo B-100 ratio. These observations,
in conjunction with previous studies from our laboratory
showing that in plasma such oxidized phospholipids
are predominantly physically present on
Lp(a) lipoprotein, 5-7,9 as opposed to other lipoproteins,
lend strong support to the hypothesis that, in
the setting of enhanced oxidative stress, proinflammatory
oxidized phospholipids may, in part, mediate
the atherogenicity of Lp(a) lipoprotein.
It seems they are arguing that high Lp(a) may not be such a big deal if oxLDL is normal. If so, that would be sweet news to me, especially since I have not been able to locate any published data showing lowering Lp(a) provides clinical benefits.
ETA: This line of thinking is reinforcing for me that oxidation and inflammation are probably my two primary battles to fight for brain and heart health given my existing coronary calcium scores and autoimmune issues.