Here’s my story of how I came here and what I’ve been working on healthwise. I would really appreciate any feedback.
I’m a 48 years-old man with E4/E4. I have a BMI of 22.5, body fat around 13%. I’m married with two kids. I have a desk job but get up every 30 minutes or so to walk about. I do strength training twice a week, bicycle with my dog every morning and have added 30-minute walks into my program (I was an avid runner but kept getting sidelined with injuries so pursued strength training 2 years ago). I also have a good amount of education and continue my education when I can.
I took meds for Benign Prostate Hyperplasia (BPH) from 2006, adding finasteride in 2010. I went through a stressful work situation in 2010-13 and went through a series of antibiotics in 2011-12 for sinus and prostate infections, which I think caused some gut damage. In 2012, I got GERD and took Omeprazole. In early 2013, I was trying to resolve some nerve pain on my foot and the doc tried Gabapentin. That threw me into a complete brain fog and caused anxiety. Even when I ended that experiment (3 weeks), the brain fog continued at a lower level. I also had mild depression and afternoon fatigue.
By December 2013 I couldn’t stand the brain fog any longer and pursued dietary changes (my doc was not convinced I had a problem). I got rid of gluten and stopped taking finasteride. This improved my brain fog. I removed the other BPH drug in February 2014. I researched a paleo diet and by April I was grain free, alcohol free, and coffee free (one cup of tea per day). I continued to feel better. I titrated off Omeprazole (not fun) using Rantitidine. By August I was reflux free and drug free. The reflux comes and goes and I’ve identified some trigger foods (excess fruit, excess fodmad, alcohol, large meals). I’ve added back wine and then mostly took it out. I’ve added back coffee but keep it low because I now seem to be very sensitive to caffeine.
I did try a low carb diet but felt like crap. I added back in one sweet potato a day and that cleared it up.
By December 2014, I was finally tested and learned that I had low Testosterone. Going on Testosterone Replacement Therapy (TRT) pretty much cleared up my remaining brain fog. I also have learned that I’m very sensitive to inadequate sleep.
I started seeing a functional medicine doctor in February 2015. He diagnosed me with methane SIBO. I’ve gone through the gamut of natural antibiotics, pharmaceutical antibiotics, and now a high prebiotic and probiotic protocol. We’ll see if this ever gets resolved. I think a healthy gut is foundational to healing so I’m giving it the college try.
I learned through my various food additions/subtractions that I have a problem with eggs (itchy skin - maybe just the whites?) and garlic (tingling sensations in my feet).
I started to see another functional medicine doctor to see if I could transition off TRT. He did a full lab panel, which included the APOE test. When I learned of my 4/4 status, I shifted my diet away from red meat and dairy products toward lower protein overall keeping a good amount of fish and some chicken in the diet and added in the 30 minutes walks.
I went back and recorded all my blood work over the years. Here are some results:
06’ 11’ 12’ 13’ 14’ 15’ 16’
Glucose: 96 // 96, 109 // 104, 76 // 109, 99 // 103, 87 // 102, 97, 105, 99, 95 // 111, 98
HbA1c: 5.6, 5.7, 5.3 // 5.7 (2015-16 only)
Avg Glucose: 114 // 116.9 (2015-16 only)
Vitamin D: 23.9 // 29.8 // 38.7 // 32.9, 28.6 // 29.3, 33 (2011, 12, 14-16)
Insulin: 4 (2016 only)
Before Paleo, my lipids were so-so. Here are my two 2013 results:
TC: 185, 161
LDL: 118, 96
HDL: 50, 47
Tri: 95, 92
After Paleo, my lipids shift a good bit. 2015-16 results:
TC: 247, 220, 227, 191, 259
LDL: 166, 135, 148, 129, 187
HDL: 68, 73, 62, 48, 67
Tri: 68, 60, 82, 72, 79
My latest test earlier this year had the advanced markers:
Apo B: 126
LDL-P (NMR): 1905
Small LDL-p (NMR): 641
Apo A-1: 168
Clearly all those results were before my recent dietary change. I will try to retest in another month.
Here are my current supplements:
Pregnenolone and DHEA
Pre/pro biotics: ProFiber select, Biotagen, Primal Defense, Ther-biotic
O.N.E multivitamin (includes methylated Vit B*, D3, alpha lipoic acid, coQ10, zinc)
Vitamin C, 1000 mg
Magnesium 200 mg
Vitamin D3 2000 IU (thinking of increasing)
Experimenting with Active B12* and Super Bio-Curcumin
*I am homozygous for MTHFR (A1298C) C/C
OK, huge data dump. I’m very interested in your thoughts and suggestions.