new e3/e4

Newcomer introductions, personal anecdotes, caregiver issues, lab results, and n=1 experimentation.
Nancy
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Re: new e3/e4

Postby Nancy » Thu Sep 08, 2016 8:59 am

Yes, that seems to be the case. Inflammation in the brain seems to be a cause. There are a lot of possibilities: the brain insulin resistance (type 3 diabetes), head injuries, toxins such as mercury, infections like Lyme disease, etc.
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Re: new e3/e4

Postby Lucy5 » Fri Sep 09, 2016 10:03 pm

Mac wrote:
I think we are still searching for the root cause to neuronal death, and the plaque and tau are end effects?

Hi Mac, I've found this Alz.org overview braintour helpful re: the generally understood progression of LOAD, (starting w/slide #8), w/o getting into the endless possible causes/triggers of the disease.

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Re: new e3/e4

Postby MAC » Sat Sep 10, 2016 8:10 pm

Thanks Lucy5.

Been doing more reading, trying to find the latest papers on better AD root cause underlying science.

Here are few that relate to "fatty acid" proteins found as strong biomarkers for AD:

http://www.nature.com/articles/ncomms11934

http://www.ncbi.nlm.nih.gov/pubmed/2093 ... olding=npg

https://www.ncbi.nlm.nih.gov/pubmed/17622779

http://onlinelibrary.wiley.com/doi/10.1 ... 273.x/full

"Heart-type fatty acid-binding protein (hFABP) was identified as the most abnormal CSF biospecimen. CSF hFABP levels are known to be significantly altered in LOAD patients, having a high predictive power of the progression from MCI to LOAD states. The CSF hFABP level is significantly associated with longitudinal atrophy of the entorhinal cortex and other LOAD-vulnerable neuroanatomical regions"

How much these markets are genetic and/or diet "causing" is still to be ascertained, suffice to say reducing fat intake is likely a good general preventive protocol.
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Nancy
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Re: new e3/e4

Postby Nancy » Sat Sep 10, 2016 9:20 pm

Oh wow. Thanks, MAC.
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Re: new e3/e4

Postby Lucy5 » Sun Sep 11, 2016 12:13 am

Thanks for the links, Mac! Found the article from Nature especially interesting.

Their data-driven approach/conclusion: "We analyse over 7,700 brain images and tens of plasma and cerebrospinal fluid biomarkers from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Through a multifactorial data-driven analysis, we obtain dynamic LOAD–abnormality indices for all biomarkers, and a tentative temporal ordering of disease progression. Imaging results suggest that intra-brain vascular dysregulation is an early pathological event during disease development."

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Stavia
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Re: new e3/e4

Postby Stavia » Sun Sep 11, 2016 2:25 am

Mac, thanks for the links.
If you want to dive down the rabbit hole of correlation of dietary fat and various lipid subtractions and disease outcomes, please share your views with us. It's a hotly contested arena and quite frankly I believe nobody can be sure as there is no hard evidence, just correlation and theories so far.
We have a ginormous thread about it.
I wish it were as simple as the bulk of scientists and clinicians believing eating lower fat = less dementia.
Dietary fat content may not be related to cerebral fatty acids at all. The body is horrendously complex. And lipid metabolism too...

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Re: new e3/e4

Postby MAC » Sun Sep 11, 2016 7:41 am

Thanks Stavia...was hoping a doctor would comment!

Any comment on that recent Biogen trial drug...there have been so many failures with drugs targeting plaque? I thought I read that even though a small group trial only a "small" subgroup showed some signs of cognitive slowdown? Slowdown only?
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Re: new e3/e4

Postby Stavia » Sun Sep 11, 2016 12:37 pm

Mac I feel the Biogen data is very preliminary and am waiting for more data before getting too excited.

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Re: new e3/e4

Postby MAC » Mon Sep 12, 2016 9:57 am

Recent discovery of the peptide behaviour in (pre) plaque and tumeric.

http://msutoday.msu.edu/news/2016/alzhe ... situation/

Article on Tumeric and AD.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781139/

"Epidemiological studies have shown that prevalence of AD is 4.4 lower amongst Indian Asians as compared to people of western origin"

Does anyone take tumeric as part of a preventive lifestyle protocol? If so, method of delivery/dosage/frequency and any side effects?
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Re: new e3/e4

Postby Julie G » Mon Sep 12, 2016 10:33 am

Mac, I love your inquisitive mind. Turmeric or more precisely curcumin has been very helpful for me. I take 750mg (bioavailable) daily. I consider it to be one of my most important supplements. You might try using our search engine to explore previous discussions on turmeric/curcumin, dietary fat, etc. to take advantage of the community's earlier work.


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