Yes, that seems to be the case. Inflammation in the brain seems to be a cause. There are a lot of possibilities: the brain insulin resistance (type 3 diabetes), head injuries, toxins such as mercury, infections like Lyme disease, etc.
Mac wrote: I think we are still searching for the root cause to neuronal death, and the plaque and tau are end effects?
Hi Mac, I've found this Alz.org overview braintour helpful re: the generally understood progression of LOAD, (starting w/slide #8), w/o getting into the endless possible causes/triggers of the disease.
"Heart-type fatty acid-binding protein (hFABP) was identified as the most abnormal CSF biospecimen. CSF hFABP levels are known to be significantly altered in LOAD patients, having a high predictive power of the progression from MCI to LOAD states. The CSF hFABP level is significantly associated with longitudinal atrophy of the entorhinal cortex and other LOAD-vulnerable neuroanatomical regions"
How much these markets are genetic and/or diet "causing" is still to be ascertained, suffice to say reducing fat intake is likely a good general preventive protocol.
Thanks for the links, Mac! Found the article from Nature especially interesting.
Their data-driven approach/conclusion: "We analyse over 7,700 brain images and tens of plasma and cerebrospinal fluid biomarkers from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Through a multifactorial data-driven analysis, we obtain dynamic LOAD–abnormality indices for all biomarkers, and a tentative temporal ordering of disease progression. Imaging results suggest that intra-brain vascular dysregulation is an early pathological event during disease development."
Mac, thanks for the links. If you want to dive down the rabbit hole of correlation of dietary fat and various lipid subtractions and disease outcomes, please share your views with us. It's a hotly contested arena and quite frankly I believe nobody can be sure as there is no hard evidence, just correlation and theories so far. We have a ginormous thread about it. I wish it were as simple as the bulk of scientists and clinicians believing eating lower fat = less dementia. Dietary fat content may not be related to cerebral fatty acids at all. The body is horrendously complex. And lipid metabolism too...
Thanks Stavia...was hoping a doctor would comment!
Any comment on that recent Biogen trial drug...there have been so many failures with drugs targeting plaque? I thought I read that even though a small group trial only a "small" subgroup showed some signs of cognitive slowdown? Slowdown only?
Mac, I love your inquisitive mind. Turmeric or more precisely curcumin has been very helpful for me. I take 750mg (bioavailable) daily. I consider it to be one of my most important supplements. You might try using our search engine to explore previous discussions on turmeric/curcumin, dietary fat, etc. to take advantage of the community's earlier work.