julespaps wrote:and there in bold black letters was the details that I feared I was indeed a 4/4 variant
Welcome. I too am a 4/4 and want to address your question,
julespaps wrote:Is it all doom and gloom or do us E4's have a fighting chance.
No, it's not all doom and gloom! Fighting chance? Absolutely! The ApoE4 allele has served man well since man evolved to become human. It's the other alleles that mutated, and they only came about recently in evolutionary terms, so I feel ApoE4 has lots of beneficial attributes, it just needs proper care and feeding. Unfortunately, the diet and lifestyle of modern man does not serve our genotype well, but these are things that can be addressed.
There's lots of ammunition out there for you to win the fight. This journey has been a very positive experience for me. I thought I was basically leading a healthy life before learning my ApoE4 status but I've learned so much as a result of this journey. I learned I was doing things that really weren't so healthy. I've made some diet and lifestyle changes and have been grateful for every moment since learning my status to be able to employ strategies to beat this beast before it has a chance to raise its ugly head.
There's popular saying, 'genetics are not destiny." Just because we have to live in room with certain furniture doesn’t mean we can’t rearrange the furniture! SO MUCH can be done to influence one’s genes. The good news is what's good for mitigating Alzheimer's risk is also good for mitigating cardiovascular risk, cancer, rheumatoid arthritis, on and on. Granted, it takes some work, there's conflicting and immature information out there, but if you just sit there and say, “woe is me” well, you’re going to get what you ask for, “woe.”
You've made a great first step by finding this website, it is a great resource, but I will acknowledge it can be overwhelming to a newbie. I lurked a LONG time before my first post. I didn’t want to sound stupid, especially since some of the subjects are addressed at such a rapid-fire pace and high level, it can be hard to keep up. Don’t let it be overwhelming, hang in there. Read the primer, read the wiki, read Dr Bredesen's book, read some of the other books recommended in the forums, search the threads to learn certain answers you're looking for, learn and don't forget to LIVE. At 47, you're in an ideal position to live a long healthy life.