Set it to 1 pound per week, agreeing with Gundry that the faster it comes off the faster it comes back.
Very reasonable, drae. I suspect I speak for many when I say I'm blown away by the many positive changes you are making in such a short period. You exemplify what we represent. -xo
Interestingly, ketosis offers smaller gains in cognitive performance to APOE4 carriers with Alzheimer's than to non-carriers with Alzheimer's.
https://www.ncbi.nlm.nih.gov/pmc/articl ... figure/F4/
Searcher, look at Figure 3 of the Henderson paper. After 90 days of treatment the highest BHB reading was 0.4 mM. That’s pitifully low and not even in the ballpark of what Dr. Bredesen recommends. The interesting point is that even that tiny amount was able to exert a positive cognitive effect on non-E4 carriers. We can guess that E4 homozygotes, who are at a much greater disadvantage in terms of a neuronal fuel shortfall, may need more For instance, I wake up with 0.8 and often get to to 3.0mM through the day by combining fasting, exercise, and a low carb diet. Cunnane has demonstrated in this paper that KBs can replace some part of that neuronal shortfall. What we don’t know is if this will be enough to prevent (or overcome) AD. We just don’t have the studies.
Re. your concern about MCT, I think it’s leap to extrapolate a mouse study to humans, but completely respect that you’re convinced. Either way, Dr. Bredesen considers insulin resistance, combined with cognitive decline, to be a medical emergency *a neuronal fuel crisis* and he recommends the use of MCT for a short transitional period while his patients heal. Using this method (combined with fasting, exercising, and a low carb diet) he’s been able to restore insulin sensitivity and improve cognition.