Welcome, Thrive! Your choice of name tells me immediately of your positive nature and intentions.
Further testing is always an individual choice. Focus on diet and lifestyle is the cornerstone for good health going forward, and you seem to be well ahead of the curve in that regard. That said, many on the site have run their 23andMe raw data through various avenues for further interpretation. [[[ Examples: https://promethease.com/
(Dr. Rhonda Patrick, who is E3/E4), Strategene https://www.drbenlynch.com/product/strategene/
(Dr. Ben Lynch, who also has a recent book out, Dirty Genes ). ]]] Functional Medicine’s James Maskell shares Viome’s interpretation of his genetic testing here: https://www.youtube.com/watch?v=K46Ffwpd_gE
Many on the site do quite a lot of baseline testing. Reference points help us interpret results more clearly, and can show us emerging patterns we might otherwise miss. You can evaluate all that is recommended, and decide which you think would benefit you in future.
Being homozygous for E4 elevates your risk for ‘late onset’ AD. Site founder and president Juliegee speaks about issues she began noticing in this video: https://www.youtube.com/watch?v=KDnrN--NVYM
It’s important to remember that genetics is not destiny. So many factors play into the future, and which genes do – or do not – turn on. And you don’t want to lose focus about other issues involved, including the possibility of cardiovascular disease.
You're familiar with Bredesen, Mercola and Perlmutter - wonderful sources. Please let me mention one other, Dr. Steven Gundry. He is a cardiologist, who has extensive experience in treating E4s, and is followed by many members on the site - who have in some cases shared their continuing excellent results with us.
We have interns on the site, who will soon greet you, and point you toward some of the practical aspects of the site. Meanwhile, we look forward to more questions, and to what I know will be valuable contributions from you in the future.