Ades81832 wrote:Hi, I’m 37 years old, My 23 and me report says APOe4/e4 But Prometheus report say E1/E4. So is that even worse than E/4 E/4. Or even more ancient? Or possibly better?I had a higher percentage of neanderthal dna as well. I’ve always had lower HDLs but everything else is normal. I gained a ton of weight when I was pregnant. 3 times. Like 80 pounds? I don’t think I ate too much more, it was very strange. Normal HDLs through pregnancy.
Hello Ades81832 & A Very Warm Welcome To Our Community!
I'm sorry to hear about the confusion regarding your testing results. Thank you for sharing, as other members have experienced similar situations and we can all learn from and support each other.
Firstly, I want to acknowledge that regardless of your APOE testing status, you are already taking proactive steps like reaching out to your community. You are also young and have many years to optimize your cognitive and overall health using preventative measures, such as a focus on lifestyle factors. You will find additional information regarding the risk of developing Alzheimer's based on the APOE gene variants via the ApoE4.Info Wiki
and on page 11 of Dr. Dale Bredesen's book, The End Of Alzheimer's
. According to Bredesen, your risk of developing Alzheimer's increases to over 50% with two copies of the E4 variant (E4/E4). The great news is that genes only account for 25% of our profile and whether our genes are expressed depends on a variety of lifestyle factors such as diet, nutrition, sleep, stress, relaxation, exercise, relationships and toxin exposure. The Primer
is another fantastic resource exploring areas such as the science behind the ApoE4 gene and the lifestyle factors that impact its expression. It is beautifully compiled by Stavia, a physician, member and E4/E4.
In terms of the weight gain during pregnancy, I'm curious to know if you ever had your thyroid levels checked.
Wishing you well and again a warm welcome:)