Congratulations on happy results from 23 & me!! My guess is that 23&me got it right and that the EARLY trial of JNJ-54861911 has also not made a mistake: they are more interested in the fact that you're a healthy 73 year old with a family history of dementia.reluctantexan wrote:23andme results are in. Promethease Report in. I appear to be one of the luckiest people in any gene pool. Maybe I just can't read the results properly. APOE E3/E3, no variants for any diseases. Makes me wonder how I got into this AD Study. Does 23andme ever get the wrong results?
On the EARLY trial, you don't have to have ApoE 4, but if you don't have ApoE 4, you do have to have a first degree relative (parent, sibling) who had some kind of dementia because parental history of dementia is itself considered an independent risk factor for dementia.
And that's just to get into the screening portion of the study, which is what you've been "accepted into." [That was confusing for me too when I was "accepted" and signed consent for the Generation 1 Screening. I didn't realize there would be a whole separate consent for the actual study,]
The four hours of tests you had recently is indeed exhausting, but at least you know you "passed" as cognitively AOK! They now want you to go on to the MRI, mostly to be sure you don't have any factors that would prevent you from safely participating in the study, or some early indications of changes that would keep you from being included.
After that is the PET scan (which I found very relaxing: think warm blanket and a quiet machine, in comparison to the MRI clatter). The EARLY trial does want to find a "positive" result for amyloid in the brain. Having amyloid in the brain at age 73 doesn't mean you're going to get AD; 30% of people without dementia who donated their brains to an AD study, were found to have positive amyloid while being "asymptomatic" for mild cognitive impairment or dementia.
The reason they want to have a positive amyloid result (I think for both Apoe 4 and Apoe 3's) is to "prime the pump" for their drug, which is designed to reduce amyloid to very low levels.
I would suggest that you call the Study Coordinator and ask about the 23 & me results, and clarify if it's true that you need to have a positive amyloid result on the PET scan. I am sure they gave you a cheek swab on your first visit, and they know that you're a 3/3 also.
Here's the source from Clinical Trials.gov for this info on the EARLY trial:
https://clinicaltrials.gov/ct2/show/NCT ... 911&rank=3
Best of luck whatever you decide!