jordansmom wrote:I am a married, 48-year-old female scientist living in Arlington, VA. I just found out I carry one copy of the apo e4 allele via a 23andMe home DNA test. I'm hoping that connecting with people on this forum will give me information on clinical trials for which I might be eligible, as well as practical tips for mitigating the genetic risk of late-onset. I'm thinking about asking my GP to put me on statins, as I've heard statin us diminishes AD risk. I'm also on a very low dose of Effexor, which I've been taking since 2007; I've also read that SSRIs (low-dose Effexor is SSRI-like) may be neuroprotective, although other studies conflict.
Anyhoo, that's about it. Glad to be here.
Jordan is a lucky child to have a mom who has taken excellent care of herself and is calm enough to be thinking already about how she can manage the news she "just got" in ways that will help both her and others (in clinical trials). Being a Ph.D. toxicologist sounds like great training to look at scientific claims about Alzheimer's disease and its prevention with an informed, yet skeptical eye. (And along the way, you can help those of us who were English majors decode some of the mysteries!)
Since you probably have institutional access to any scientific journal you could want, I won't presume to tell you which to go after. But I will share some articles I found helpful, after I learned of my 4/4 status at the age of 62, 4 years ago.
As for clinical trials of investigational drugs for prevention, you're (luckily) still too young for those. An advanced search on ClinicalTrials.gov for trials recruiting healthy volunteers within 50 miles of Arlington for Alzheimer's research didn't turn up any that went down to age 48; the youngest was 55. I am in the Generations 1trial for 4/4's who are between 60-75 and still cognitively healthy, which has an arm for CAD106, an immunotherapy drug, and CNP520, a BACE-1 inhibitor. I am in the BACE-1 arm, although of course I don't know if I'm in the 62% who are receiving the drug or the 32% who are an important placebo control group. A similar large scale trial of a BACE-1 inhibitor, called the EARLY trial, is now enrolling people with Apoe 3/4 and 4/4 ages 60-85 in the US after starting a few years ago in Europe and will likely also have preliminary results in 2024 or so. Other trials, in other areas of the country, include studies of the MIND diet, yoga, and other lifestyle interventions. By the time these trials report out results in 5 years or so, you will still be young enough to benefit if they show significant results in biomarkers of clinical progression before MCI or AD, or in rates of conversion to MCI and AD.
Right now you are at a great age to continue the healthy habits you've maintained thus far, and may want to check out this lengthy forum thread on the subject of hormone replacement therapy for future reference: Hormone Replacement Therapy for E4 Women
BTW, I have family in nearby Alexandria, so can say with confidence that you live in a great area to access cutting edge research centers and medical professionals who can support whatever steps you decide to take. Enjoy your second, unofficial Ph.D training topic, and enjoy being Jordan's mom!