I am a married, 48-year-old female scientist living in Arlington, VA. I just found out I carry one copy of the apo e4 allele via a 23andMe home DNA test. I don't know my full haplotype or status of any of the other genetic risk factors for AD, early-onset or late-onset. I do have a family history of late-onset AD: my paternal grandmother was diagnosed when she was ~80 years old and died of it when she was 87. My dad is 78 years old, but, AFAIK, he has not been diagnosed with dementia of any type, although he tells me that, when he was either in his late 50s or early 60s, an MRI scan had shown that his brain had shrunk, and he's lost points on an IQ test administered at the time. He'd originally gone to the doctor with a complaint about being unable to remember people's names. His dr put him on Aricept, which he quit shortly after taking it due to side effects. He was employed at least part-time as a mechanical engineer until he was 72, after which he hasn't worked. My guess is that my dada does have late-onset AD, but that the progression is very slow. My mom, and her side of my family, have no history of AD. They do have an extensive history of heart disease, though, with the women in the family dying early of heart attacks.
I'm a Ph.D toxicologist by training and did a rotation through an AD lab during grad school, so I'm familiar with the medical literature of the pathology and pathogenesis of the disease. I'm hoping that connecting with people on this forum will give me information on clinical trials for which I might be eligible, as well as practical tips for mitigating the genetic risk of late-onset. So far, my strategy has been (since my 30s at least), to keep my weight stable and within normal range; daily, intense exercise; keep to as healthy a diet as I can (lots of vegetables, beans, whole grains, flaxseed, nuts, small amounts of lean protein; staying away from sugar, sat fat, fried foods, junk); and refraining from smoking or binge-drinking (I do like my two glasses of wine a night, though). I try to get as much sleep as I can, but I have difficulty due to RLS and tend to wake often during the night. My cholesterol is high too--~260--although most of it is HDL. I'm thinking about asking my GP to put me on statins, as I've heard statin us diminishes AD risk. I'm also on a very low dose of Effexor, which I've been taking since 2007; I've also read that SSRIs (low-dose Effexor is SSRI-like) may be neuroprotective, although other studies conflict.
Anyhoo, that's about it. Glad to be here.