Page 1 of 1

Help with APOE snps

Posted: Wed Sep 19, 2018 1:23 am
by Alrklein
Hello, i have been concerned about cognitive decline for a couple of months now, and went back to 23andme and they seem to have a new Alzheiners report which shows me at slightly grater risk.

In terms of e3/e4 etc i cant seem to inrepret my data

The 2 heterozygous snps i have are :

Rs429358 CT +-

Rs769449 AG +-

Can anyone interpret?

Thank you

Re: Help with APOE snps

Posted: Wed Sep 19, 2018 5:48 pm
by Matisse
Please also provide results for RS7412 to determine full apoe status.

Re: Help with APOE snps

Posted: Wed Sep 19, 2018 6:11 pm
by slacker
Alrklein wrote:Hello, i have been concerned about cognitive decline for a couple of months now, and went back to 23andme and they seem to have a new Alzheiners report which shows me at slightly grater risk.




Hi Alrklein;

23&me gives its clients raw data, which needs to be converted into easier to interpret results. This can be done with a variety of tools such as Promethease. You can find out more about Promethease by doing a search (magnifying glass in tool bar right upper corner of website) on "promethease", but you'll ultimately need to go to their website to get the job done.

Good luck, and welcome!

Re: Help with APOE snps

Posted: Thu Sep 20, 2018 12:55 am
by Alrklein
Matisse wrote:Please also provide results for RS7412 to determine full apoe status.

All others are —

RS7412 is CC thanks

I will look at promethease

Many thanks

Re: Help with APOE snps

Posted: Thu Sep 20, 2018 8:49 am
by Chameleon
Welcome Alrklein to the APOE4 website. Kudos to you for getting the test done and getting them Interpreted.

If you are comfortable, let us know what your experience was with Promethease and how it turned out for you.

You may also want to check out the Primer that Stavia wrote, which contains wonderful information.
Please feel free to continue asking questions and sharing your journey.

We look forward to hearing more from you!

Re: Help with APOE snps

Posted: Thu Sep 20, 2018 10:13 am
by Matisse
You are apoe 3/4. Promethease will confirm it as well as give lots more info.