hairyfairy wrote:I have two genetic markers for this eye disease
Hi Angelheart301,Angelheart301 wrote:I am APOE 3, 4 and also have rs10490924(T;T) and rs11200638(A;A) which according to Promethease increase chances of AMD and wet AMD by 8X and 10X. Last fall (at age 71) straight lines suddenly started to look wavy (door frames, windows, floor tile, etc), I was diagnosed with dry AMD in one eye and wet AMD in the other. I went to Wills Eye Hospital to their top retina specialist...
hairyfairy wrote:Iv`e read about the apoe4 gene being linked to macular degeneration as well as AD. My genetic test results also showed that I have two genetic markers for this eye disease. It`s bad enough having an AD gene without having to worry about blindness as well!
A growing body of scientific evidence suggests that enrichment of certain nutritional compounds in the brain may reduce the risk of Alzheimer’s disease (AD).
To investigate the impact of supplemental xanthophyll carotenoids plus omega-3 fatty acids on disease progression in patients with AD.
Three trial experiments were performed. In Trials 1 and 2 (performed on patients with AD over an 18-month period), 12 patients (AD status at baseline: 4 mild and 8 moderate) were supplemented with a xanthophyll carotenoid only formulation (Formulation 1; lutein:meso-zeaxanthin:zeaxanthin 10:10:2 mg/day) and 13 patients (AD status at baseline: 2 mild, 10 moderate, and 1 severe) were supplemented with a xanthophyll carotenoid and fish oil combination (Formulation 2; lutein:meso-zeaxanthin:zeaxanthin 10:10:2 mg/day plus 1 g/day of fish oil containing 430 mg docohexaenoic acid [DHA] and 90 mg eicopentaenoic acid [EPA]), respectively. In Trial 3, 15 subjects free of AD (the control group) were supplemented for 6 months with Formulation 1. Blood xanthophyll carotenoid response was measured in all trials by HPLC. Omega-3 fatty acids were profiled by direct infusion mass spectrometry.
Xanthophyll carotenoid concentration increases were significantly greater for Formulation 2 compared to Formulation 1 (p < 0.05), and progression of AD was less for this group (p = 0.003), with carers reporting functional benefits in memory, sight, and mood.
This preliminary report suggests positive outcomes for patients with AD who consumed a combination of xanthophyll carotenoids plus fish oil, but further study is required to confirm this important observation
johndoealzh wrote:I have the same genetic combination. Im taking Areds 2 and I feel like my proper nouns are coming to me a little quicker since. But I can't prove that. I'm 63.
johndoealzh wrote:Not likely. I was on the AREDS2 for about 4 months before I got on the CNP520/Placebo. And my results for the Amyloid PET scan, which the Gen 2 Study gives you an initial result only on, was Not Elevated. I should be careful on this site not to give out too much info about by case, bit I think this is OK.
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