Glad to help!Punch wrote:thank you for explaining this so cogently. Altho I love math, I've never quite grasped this concept of statistical increase in my bones. It's the same logic as used for breast cancer. I *sorta* get it, but I don't think I could explain it to anyone else convincingly. You're right, my provider did not explain my r3/4 risk very well. He was shy and avoidant, as if dropping catastrophic news on me. He also knows both my parents have cognitive impairment, but in both cases it was brought on or at least aggravated by a fall.
You have lots of time and resources to improve your protective factors and your resistance to effects of ApoE 4. And the research on this is booming--way beyond just what is in the news on failed drug trials.
Your parents may want to try a few modest strategies themselves, if gently suggested by you. Even something as simple as getting their B-12 and Vitamin D levels checked could be important. Dr. Stavia's Primer lists Basic Strategies that might not disrupt their lives too much.
About 100 clinical studies in the U.S. are also looking for people with mild cognitive impairment; many of these involve strategies like exercise, diet and control of high blood pressure; they are not all drug trials. Here's a link to the National Institute of Health's Clinical Trials database, with a map that show studies by U.S. state (it also shows studies in other countries). Recruiting Studies | Mild Cognitive Impairment | Older Adult