paul820 wrote:Hi everyone, I recently did the 23andme and Ancestry DNA tests to find out about my background and genetic risk factors. When I opened my 23andme results, I was surprised to find out that I had one copy of the APOE4 gene. I dug into the raw data further and found out I'm an E3/E4 (SNP rs429358 = CT, SNP rs7412 = CC). However, my raw data from Ancestry seems to indicate that I'm an E3/E3 (SNP rs429358 = TT, SNP rs7412 = CC). Just to see if there were any other differences, I compared several other markers related to Alzheimers betwen the two data sets, yet those all matched.
Has anyone else experience a similar result? If so, did you request a re-test from either company? I paid over $100 extra to obtain the 23andme results, so I'm more inclined to believe that result. However, you'd think for a gene with such high stakes, there would be more consistency between different testing services.
Julie G wrote:Welcome, Paul! You're not alone with a mismatched result. Ancestry.com doesn't provide APOE data and has historically used a used a 3/3 default. We discuss it in this thread and probably others. I'd be inclined to go with the 23andMe result although even that one isn't 100%.
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