Brother and sister neg for apoe4 - feeling oddly alone now...

Newcomer introductions, personal anecdotes, caregiver issues, lab results, and n=1 experimentation.
thlas1971!
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Brother and sister neg for apoe4 - feeling oddly alone now...

Postby thlas1971! » Sun Jan 06, 2019 5:18 pm

I don’t want them to be positive... truly I don’t. My gut is pathetically wondering why I swam in the shallow end of the gene pool. I’m hopeful you all can understand my strange mixed emotions right now.
Teresa APOE3/4

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TheBrain
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Re: Brother and sister neg for apoe4 - feeling oddly alone now...

Postby TheBrain » Sun Jan 06, 2019 6:38 pm

I understand how you feel. I’m 4/4, and the only one of my three sisters who has been tested is 3/3. I’m happy for her, but a child part of me feels it’s unfair. Why me?
ApoE 4/4 - When I was in 7th grade, my fellow students in history class called me "The Brain" because I had such a memory for detail. I excelled at memorization and aced tests. This childhood memory helps me cope!

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Re: Brother and sister neg for apoe4 - feeling oddly alone now...

Postby Plumster » Mon Jan 07, 2019 1:50 pm

Yep, my brother is 3/3. Lucky bastard.
e3/4 MTHFR C677T/A1298C COMT V158M++ COMT H62H++ MTRR A66G ++ HLA DR

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slacker
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Re: Brother and sister neg for apoe4 - feeling oddly alone now...

Postby slacker » Mon Jan 07, 2019 4:13 pm

but we all have new family here on the site! How fortunate!
Slacker
E4/E4

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Re: Brother and sister neg for apoe4 - feeling oddly alone now...

Postby WifeOfJoel » Mon Jan 07, 2019 5:47 pm

What you're feeling is normal.

I resonate with your feelings in a non-ApoE4 context - as a person who is 39 years old, without children, every time one of my younger brothers or a 25-year-old cousin of mine announces their pregnancy. At those times, I feel a weird mix of happiness for them, sadness from wanting children but not having them, and guilty feelings from not being completely overjoyed for these people I love.

At those times, I talk to someone I trust, and then focus on what I can do - for example, in my case, I'm researching methylation and methyl folate therapy for my homozygous MTHFR mutation (and how it relates to childbearing).

You have done well by finding out about your genetics, and doing something about it! And my friend reminded me (today in fact, when I told her about my MTHFR mutation), we all have mutations, so if it's not one, it's another. ApoE4 is one you can do something about! :)

physician scientist
Me: APOε3/3, MTHFR (C677T) homozygote
Partner: APOε4/4
Mother: APOε3/4

Torimintz
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Re: Brother and sister neg for apoe4 - feeling oddly alone now...

Postby Torimintz » Wed Jan 09, 2019 5:10 am

I think we all can relate. I'm sure that I have siblings and cousins both with a 4 , and some who don't at all have a risk... and I feel the same. There is an issue with me too in that I see my declining mother, and there was an uncle of her's (who had it in his 80s as well), and the two of them were amazing in comparison to so many of the other 80 year old relatives... yet, some get it... while others who are eating terrible food, drinking, smoking... etc... may never get it and live til their 90s.... CRAZY!
This is life though. I truly feel for those people who get the SUPER early kind that comes in the 50s... which isn't related to the APOE4

thlas1971!
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Re: Brother and sister neg for apoe4 - feeling oddly alone now...

Postby thlas1971! » Wed Jan 09, 2019 11:24 am

Thanks for all your responses. I totally feel the love and support. I also loved slacker's comment about having a new family here. :) So many emotions around Alzheimer's. My mom continues to decline too, Torimintz. She was asking yesterday to go stay with her grandparents for a few days. :(
Teresa APOE3/4


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