kytexas wrote:Things I continue to research and look forward to more data on :
the perfect diet for my epigentics/NAD/MCT Oil/Metformin/peptides/sarcopeia/protein/alcohol consumption/
I'm 67 years old and also exercise regularly. I am not diabetic, but I started taking metformin last February after listening to several discussions of its anti-aging benefits on Peter Attia's podcast episodes.
Peter sent an email today referencing a New York Times article
, The article says metformin blunts the health benefits of exercise in healthy older adults. Metformin diminishes improvements in skeletal muscle mitochondrial respiration, cardiorespiratory fitness, and whole-body insulin sensitivity after aerobic exercise training.
The mechanism of this blunting is likely because metformin is anti-inflammatory, and reduces reactive oxygen species (ROS) and oxidative stress. Those are good things if you have a chronic condition like T2D, but they are bad for acute episodes of stress such as follow exercise since inflammation and ROS signalling appear to trigger the hormetic response that builds muscle and cardiorespiratory fitness.
Peter is trying to sort this out and has, in the meantime, reduced his metformin dose to one a day in the evening to distance it from his exercise sessions. Since I'm older than Peter, and growing and preserving muscle mass is more difficult at my age, I am probably going to discontinue use altogether, although I may do it in two steps with evening-only use for a couple of weeks.