Welcome, Afraid,Afraid wrote:I did a consumer genetic test and worry about my ApoE status because I see a conflict between my ApoE alleles based on rs429358 and rs7412 with the predictive SNPs like rs4420638 and especially rs769449.
The minor alleles of these SNPs are commonly co-inherited with an ApoE4 allele and I am heterozygous for both, yet according to rs429358, I am ApoE3/3....
I never had been this insecure about my health and it is a heavy weight on my shoulders.
All thoughts about this and how I should go on are very welcome.
NF52 wrote:So here's a question for you first: I put "bold" font on your statement that according to rs429358 you are ApoE 3/3. That Snp, if it came back as "T', would indicate that you have one ApoE 3 (assuming it was correct). But you would also have to look at the result of rs7412, which would be "C" if that is also ApoE 3, according to the handy chart on SNPedia: https://www.snpedia.com/index.php/APOE. Are those the results you received?
NF52 wrote:One other possibility: you didn't say which consumer company did your test. If it was 23&me, they seem to have about a 99% accuracy rate, and have sometimes confirmed results when people ask them to check. If it was Ancestry, they seem to always return a result of ApoE 3/3, for reasons I don't understand. Here's a forum thread on that subject.APOE mismatch Ancestry vs 23andMe
I hope you'll be able to untangle this through either Promethease or using another testing service and will let us know the results.
Afraid wrote:Thank you very much for welcoming me with such an awesome and in-detail reply.
I can only thank again for the welcome and information you provided me with. It greatly helped mitigating my fear. Hopeful that the time until definitive results are in will not have me in the same anxiety since realizing that there is something not right.
NF52 wrote:If so, then it seems you are in fact ApoE 3/3. As for the 2007 article you cited showing a miniscule chance of having a different SNP result on rs4420638 and especially rs769449 that is usually linked with ApoE 4, I would say that genome wide association studies have progressed exponentially in the last 12 years.
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