A warm welcome, Jenn!CuriousJJ wrote:Hi,
Just in case you don't want to read through my lengthy intro, here is my first question:
What is your favorite genetic tool for taking the data from 23andme and ancestry and analyzing it further?
I am currently about to turn 48...
p.s. 23andme results for my daughter indicated she had 1 Apoe4 allele? and was at a slightly increased risk for late onset of AD. (hope I used the terminology properly)
The Generation Study elected to disclose the following “lifetime” risks of MCI or dementia to its potential participants: 30%–55% for individuals with APOE-e4/e4; 20%–25% for individuals with APOE-e3/e4 and -e2/e4 (with a note that risk might be lower for those with APOE-e2/e4); and 10%–15% for individuals with APOE-e3/e3, -e3/e2, and -e2/e2 (with a note that risk might be lower for those with APOE-e2/e3 and -e2/e2).
floramaria wrote:Hi Jenn,
Welcome to the site and to the community. My favorite tool for getting more information from the 23 & Me and Ancestory is Promethease.com. they can use your sign in information to access raw data from company you tested with, and give a report that includes a last of information.
thank you for giving your detailed introduction. Your feeling overwhelmed by all the medical information is a common reaction. There is a lot to digest. ... We are happy you have joined us and look forward to hearing more from you!
NF52 wrote: We love "lurkers" who join; I should know; I'm one of them! It shows that you have a curious, yet cautious nature and want to get information from lots of sources. That sounds like "cognitive reserve and flexibility"--two traits associated on population studies with both long life and healthy brains.
As for your # 1 question, I used Promethease, and appreciated the easy-to-read "reports" and the ability to filter by topics or risk analysis. Here's a recent thread with a post from user "Its Me" about Promethease. Others may chime in with different ideas.
Since you already have your daughter's 23&me results, your family can safely say she got that one ApoE 4 allele from either you or your hubby (who has a great sense of humor, which is a prerequisite for a great spouse!). About 20-25% of people with European ancestry also have at least one ApoE 4 allele, so it's not rare.
So you can see that your daughter, if she's in her 20's, has about 40 years for science to improve the already good 75-80% odds that she WON'T get MCI or AD.
CoachJD wrote:welcome CuriousJJ! We're so happy that you decided to do more than lurk and that you've joined the community. I know you'll find the information and the people helpful and caring. I'm sure you've discovered from your reading that your ApoE status is just a risk factor and not a determinant. You are young, smart and engaged in your own wellness journey, and have time and resources to give yourself and your family the best chance for healthy and happy senior years. I know that the information can feel overwhelming, but go slow and reach out for help as you need it. There are some remarkable contributors on this site who can help you make sense of it as you go. We hope to hear more from you!
CuriousJJ wrote:NF52 wrote:
My daughter's ancestry came back at 98% European, so that 4 allele is not a surprise, however, how she managed to NOT inherit any of my "Alienness" is a mystery.
CuriousJJ wrote:Since then, I have read up on AD, been lurking a little on this website, skimmed the Primer, read Dr. Bredesen's book, and been quite over whelmed with all the medical stuff and just how detailed it can get.
SusanJ wrote:CuriousJJ wrote:Since then, I have read up on AD, been lurking a little on this website, skimmed the Primer, read Dr. Bredesen's book, and been quite over whelmed with all the medical stuff and just how detailed it can get.
Given what you wrote, I would recommend Found My Fitness (Dr. Rhonda Patrick) and/or Strategene (Dr. Ben Lynch). These both look at genes that are important to health regardless of E4 status and how one might deal with any problem genes.
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