I'm 70, 6 ft 3 in tall, 195 lb I live in Central Texas. I have had diabetes for decades and only use metformin and Glipizide plus diet lifestyle to control it. Via Dave Feldman, I seem to be a hyper-responder relative to cholesterol. After following some of Dr. Ford Brewer's work I saw that if I had an ApoE4 status that could answer some of my cholesterol questions - especially on a Keto diet. Then that ApoE4 rabbit hole opened up a whole new universe.
I have read, watched and understand Bredesen, Gundry, Brewer, etc., etc. I get the science.
I took a 23AndMe in 2009 and from what I can find it does not have a "good" take on my APOe4 status.
It did have that my Familial Hypercholesterolemia Type B was absent.
I thought this site would be helpful if deciphering my ApoE4 status. So far not. I see rs codes, gs codes, adenine (A), cytosine (C), guanine (G) and thymine and Prometheus only gives me rs7412 with a C:C but no rs429358 and no way to tell anything about it. Other folks talk about ApoE4 Positive vs ApoE4 Negative.
I have been all over 23AndMe, Ancestry, SNPedia, Prometheus and got the Rhonda Patrick report back in 2017. I get pieces of info but nothing that ever connects the dots and confirms my status.
If this forum does not address the best way to find your status then please let me know.
I did find out on this forum that the Ancestry DNA often misreports the rs429358 as T/T.viewtopic.php?f=2&t=4785&p=54891&hilit=AncestryDNA#p54891
So good - now I know one place NOT to go to get an updated DNA test.
So, 4 questions:
(1) If my old 2009 chip 23AandMe raw data has it – where do I find what to search for.
(2) Are there “better” (likely more updated and accurate chips) test I can order today?
(3) What DNA vendor(s) are most often used successfully by forum members?
(4) Is there a thread here on HOW to find your status once you get your report?
Sorry for my terse post.