PeterM wrote:felt a little conflicted by Thuet’s lower-fat recommendations for E4 carriers.
I too was was a little disappointed by recommending a generic lower fat diet. He doesn't seem to talk from first hand knowledge, his knowledge of an E4 diet seems to have come from listening to a presentation at the ICIM conference. He right about E4s and their LDL, HDL, and VLDL being reprocessed in the liver twice as long as 3s. Oxidized LDL (oxidized = damaging/inflammatory) is generally higher in E4s because the lipoproteins float in the blood stream for such a long time. Had he recommended a lower saturated fat diet for E4s, it would have made more sense to me. I'm ketogenic and eat a fair amount of fat, but mostly monounsaturated. Through a high monounsaturated fat diet, I lowered by oxidized LDL down to reasonable levels. But it's a challenge. I know a gal who is a 3/3, she eats similarly to me, but has a petite filet of beef once a week and her oxLDL levels are always in the basement, I couldn't get away with that.