Saskia wrote:When I found out that I carry double apoE4 after a test that I mostly did to learn about my heritage I was surprised as I have no family history of Alzheimer's disease whatsoever (in my rather large family). My dad is 87 and starting to have very mild cognitive decline but nothing noteworthy. My mother is younger and fine. Not one of my grandparents or older aunts and uncles have been diagnosed with AD or shown signs beyond mild "what was I in the kitchen for again" type confusion after age 85.
Has anyone seen this bit of research (https://www.jneurosci.org/content/26/22/6069) where lack of family history of AD seems to imply a better prognosis (or at least lack of early clinically measurable cognitive decline) for apoE4 carriers? Has anyone seen other research in that area, either to confirm or disprove these findings or to attempt to find out the underlying reason?
Saskia wrote:What a great, informative and respectful forum this is.
slacker wrote:I think other members have discussed the possibility of genes that can protect against AD, and this seems likely in the situation you find in your family. Here is one for example. Hopefully someone else will chime in.
Saskia wrote:Long story short: my family's lifestyle component is at best ambiguous. I do plan to go low carb...
Saskia wrote:Has anyone seen other research in that area, either to confirm or disprove these findings or to attempt to find out the underlying reason?
SusanJ wrote:I suspect that the family history connection has much to do with other genes that increase or decrease risk. One of the best places to look quickly at your specific genes would be to use Promethease.
Saskia wrote:Are you aware of a thread in which all the other Alzheimer-related Promethease data from 23andme users is discussed that you know?
Saskia wrote:The lifestyle story is indeed interesting. To paint a rough picture - we're in the Netherlands where base levels of activity may be slightly higher than in parts of the US thanks to cycling as a common means of transport. My dad always did physical work as well as lots of running and daily exercise. My mum is moderately active. Thankfully nobody in the extended family is overweight. So much for the good behaviours. My dad smoked from his 14th until he was 75 and so did many of his brothers. Crazy - and unfair how they seem so unaffected by such a terrible habit. And in no way is our national diet low-carb. Processed foods are probably a bit less prevalent but I wouldn't bet a statistically significant difference on it! Long story short: my family's lifestyle component is at best ambiguous. I do plan to go low carb and as I'm not sure either of my parents is E4/E4 i.e. I may be the most predisposed one so far.
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