Hello, I am a 44-year old European man, with APOE3/4 (rs429358(C;T) and rs7412(C;C)), and I have the risk alleles in MTHFR (rs1801131(A;C) and rs1801133(C;T)) and MTRR (rs1801394(A;G)).
In addition to this (unrelated to APOE4, but important for health, due to a high magnitude of 4, according to Promethease), I have a high cardio vascular risk due to rs1333049(C;C).
My paternal grandmother died out of AD. The other grandmother died very young (infectious disease). None of my two grandfathers had AD. My parents so far are in a good shape.
I started a keto diet on August 2019 (unrelated to the genetic results, which I did not know at the time), since I had gained quite a lot of weight. The keto diet (supervised by a doctor; it is almost a pescetarian keto, with little meat, since I prefer fish to meat, and lots of vegetables) has made wonders on me, and I have lost almost 30kg. Now I have a BMI below 25, and I feel great. It seems as if I have rejuvenated a few years.
When I started the keto diet, I had a blood test, which resulted in high cholesterol (244 total, 171 LDL, 51 HDL and 108 triglycerides), and 13.32 micromol/L in homocystein (still in the acceptable range, but my doctor said it would be better below 10).
Now, after I did a 23andme test (the health report is not available in my country, so I ran my raw data with third party applications, like Promethease and Rhonda Patrick's FoundMyFitness), I realized that I had an APOE4 allele, and I had "bad" polymorphisms in MTHFR and MTRR.
I have read the wiki, as well as Dr. Bredesen's book. I see it will take some time to understand everything, since there are many moving parts, interrelated with each other. I see the keto diet is good for me, and I need to reduce homocystein. I am starting to supplement with methylated B vitamins (despite I had high levels of vitamin B12, 812pg/mL and folic acid (folate), at 15.20 microgr/L; I do not know if having these high levels suggest I do not need the methylated versions, or not), and choline. I also supplement vitamin D3 and K2 (since with the blood test I was at 33.3ng/mL, and I would like to go towards the optimal range, a bit higher), and a generic multivitamin, as well as EPA and DHA omega 3s. Also, my doctor recommended me to take probiotics. And I am cultivating my own broccoli sprouts, for the sulphoraphane (and they taste great).
So, looking forward to learn more, especially what it would be best for my APOE3/4, MTHFR and MTRR combination.