New here 4/4

Newcomer introductions, personal anecdotes, caregiver issues, lab results, and n=1 experimentation.
tracyrae986
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New here 4/4

Postby tracyrae986 » Tue Feb 18, 2020 12:40 pm

I am 4/4. My mother's only sister was also 4/4 (mom passed at 51 before I could test her). My Aunt S started showing symptoms early 50's, was non verbal by 60, passed at 70. I had mentally prepared to somewhat follow her path even with diet/exercise/knowledge. I just checked her rs5882 and it was A A. Mine -AND all four of my kids.... GG!!!! Here's to a bit more hope :)

Tincup
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Re: New here 4/4

Postby Tincup » Tue Feb 18, 2020 2:08 pm

tracyrae986 wrote:
Moved your post to this new subject as the original thread had not had posts since 2016.
Tincup
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Sara
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Re: New here 4/4

Postby Sara » Tue Feb 18, 2020 5:46 pm

Greetings Tracy and welcome to the apoe4.info site and thank you for sharing your family history with us! Sorry to hear that your mom passed on so early but kudos on your awareness and ability to seek out a better future for yourself and your family. Warm Regard
Certified ReCODE Practitioner/Health Coach
MBA, Functional Medicine Certified Health Coach, National Board Certified Health & Wellness Coach
Supporting loved one diagnosed with AD

NF52
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Re: New here 4/4

Postby NF52 » Tue Feb 18, 2020 5:50 pm

tracyrae986 wrote:I am 4/4. My mother's only sister was also 4/4 (mom passed at 51 before I could test her). My Aunt S started showing symptoms early 50's, was non verbal by 60, passed at 70. I had mentally prepared to somewhat follow her path even with diet/exercise/knowledge. I just checked her rs5882 and it was A A. Mine -AND all four of my kids.... GG!!!! Here's to a bit more hope :)
Hooray for hope and good genes!

Welcome from another 4/4 who is also hopeful (and an optimist) at age 67. For those like me who don't have all these wonderful SNPs down, I've borrowed a section from Snpedia:
This SNP rs5882 in the CETP gene referred to as ILE405VAL and RSAI405V has been related to ageing and exceptional long life. A study in Ashkenazi Jews showed that individuals homozygotic for the G allele have significantly longer lifespans.

OMIM 118470
Desc LONGEVITY, EXCEPTIONAL
Variant 0004
Related also
New research also indicates that G homozygotes have an average of 70% less risk of dementia and Alzheimer's disease
Snpedia: rs5882

Nothing like "exceptional longevity" and "70% lower odds of dementia" to put a feeling of spring in the air. We're so glad you found out, and shared the good news of yourself and your 4 kids. It proves what we often point out: we are each only 50% of each parent, 25% of each grandparent and 12.5% of each great-grandparent. So we have our own road to travel and can find great directions to help us on the way.
4/4 and still an optimist!

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HopefulCaroline
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Re: New here 4/4

Postby HopefulCaroline » Tue Feb 18, 2020 9:09 pm

tracyrae986 wrote:I am 4/4. My mother's only sister was also 4/4 (mom passed at 51 before I could test her). My Aunt S started showing symptoms early 50's, was non verbal by 60, passed at 70. I had mentally prepared to somewhat follow her path even with diet/exercise/knowledge. I just checked her rs5882 and it was A A. Mine -AND all four of my kids.... GG!!!! Here's to a bit more hope :)


tracyrae986,

Hello and welcome to our community. Thank you for sharing your story. I'm sorry to hear of your mom's very early passing as well as your aunt's struggle and passing from dementia. Our community members can very much identify with your story. As NF52 so eloquently said "Hooray for hope and good genes!" There is plenty of knowledge on this site that can hopefully provide value on your road to a long life. I would like to point out a few resources that may be of interest. Our Primer, written by a physician who is also a member, is an introduction to ApoE4, biochemistry, and possible prevention strategies. Our Wiki will provide details on underlying scientific concepts, specific dietary protocols, lab benchmarks as well as how to make the most of the site.

Thank you for sharing. Please reach out if we can help in any way.

Sincerely,
Caroline
Caroline
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Functional Medicine Certified Health Coach
“What grows never grows old.” -Noah Benshea


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