Welcome, Tabby, from another ApoE 4/4!Tabby wrote:I found out my 4/4 status a few months ago from 23andMe. I am an active 53 year old woman with teenagers at home...I have several questions that I hope you can answer...
In the fall of 2019, Dr. Brinton received a grant for $37 million from the National Institute on Aging to study ApoE 4 using a version of a natural steroid drug (allopregnanolone) that showed promise in actually regenerating hippocampal cells and reducing brain inflammation. it will probably study people with Mild Cognitive Impairment--but research almost always extends knowledge and opens doors for more and earlier approaches.“a wake-up call, not a death sentence”: plenty of women with APOE4 do not have the disease...The take-home message is that sustaining metabolic health sustains cognitive health,” Brinton concludes. “You can't change your chromosomal sex or age or your gene variant. But you can change your metabolic health and thus your level of risk.”
Finally, I too take 500mcg daily of methylcobalamin, originally recommended by the Study Site Dr. based on the extensive blood and biomarker testing done in clinical trials. That got my B12 levels to the mid 600's, comfortably above the 500 level recommended by both Dr. Bredesen and the Study Site Dr. I also am heterozygous for MTHR mutations, by the way. You may want to check out our Wiki on methylation, if you haven't seen it yet.Participation in DNA Relatives
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Tabby wrote: I have been lurking for several months now, studying the wiki, the primer, and the how to, but I have several questions that I hope you can answer... Thank you in advance for answering my questions. I hope it isn't too much to ask so many at one time.
Tabby wrote:How are other people getting sufficient amounts, in the correct form of EPA and DHA?
I have been trying to figure out which fish oil to get and I know we need it to be in phospholipid form. In 2014 krill oil was the thing to take. Now it appears that the levels in krill oil are too low. Are there any supplements available that have sufficient phospholipid content?I try to eat SMASH fish but I have a really hard time eating fish from a can. I have to try really hard not to see the little vertebral columns, and to force it down without gagging. I love salmon but I cant eat it every day. Also, I usually avoid eating from cans but this is how most of these fish come. I bought a small container of salmon roe which was equally hard to get down, but I found if I froze the roe, I could swallow them like little pills without chewing. How are other people getting sufficient amounts, in the correct form of EPA and DHA? Is anyone buying the roe in bulk? If so, from which company and how do you manage to eat it? Should I still be taking regular fish oil? Cod liver oil? Is there value in taking these since they are in ester form? Should I get a separate DHA supplement?
Tabby wrote:I found out my 4/4 status a few months ago from 23andMe. I am an active 53 year old woman with teenagers at home. I knew I had a good chance of getting Alzheimer's since both of my parents had it, but it was still a shock to get genetic confirmation. Both of my parents were highly educated and trim. Neither of them had heart disease or diabetes, so I am assuming their demise was mostly genetic. .
Tabby wrote:I am pretty sure my computer will suffer a slow death from all of the windows I have open looking at different threads and supplements to consider. Please, save my computer and help me make some decisions.
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