Newbie 4/4 trying to stay positive!
Posted: Fri Apr 09, 2021 7:25 am
Hello everyone, I am new here having discovered by APOE 4/4 status a couple of days ago. Yesterday I was down in the dumps and totally depressed about it all but I have had a word with myself and now I am going to be positive and focus on the good and try to continue to prevent LOAD. I just have a few questions...
My Heritage is the company which gave me the results for APOE 4/4. Should I do another test to confirm for sure? Or will this be accurate?
I also ran my raw data from My Heritage through Promethease yesterday which came up with a few other interesting bits of DNA. I think I found a few positives. If anyone knows anymore about them that would be greatly appreciated.
rs1799990 AG - resistance to vCJD, 4.6x reduced risk of Sporadic CJD and 0.87x reduced risk for LOAD.
rs10468017 CT - associated with higher HDL cholesterol
rs1061325 - two copies of 'farmer' CLTCL 1 gene variant - wasn't sure on this one because it seems to say that it means I am good at breaking down carbohydrates but also could potentially lead to insulin resistance?!
rs10936599 CC - this one just said 'longer telomeres, longer life?'
rs174537 TT - lower LDL-C and total cholesterol
rs4149268 AG - associated with higher HDL cholesterol
rs8164163 AG - associated with higher HDL cholesterol
rs261332 AG - associated with higher HDL cholesterol
rs4939883 CT - associated with higher HDL cholesterol
rs610932 AC - this was labelled as 'green' for good but didn't really say much. Just said it had some connection to AD.
rs2149954 AG - slight association with longer life (longevity)
In terms of prevention... I have been reading up lots on things which help...
Gain as high an education as possible in young age - I could read and write at 2 years old, was privately educated, gained two degrees and a professional qualification in my line of work. I would like to think I have that one covered!
Healthy diet / weight etc - I'm 5ft 3 and 8 stone 12ish so am a healthy weight. I eat freshly cooked meals at least 5 days of the week. I do like cake though... do I need to cut this out? Or would a slice or two a week matter if the rest of my diet is healthy?! Would love to know this.
Exercise - I walk my dog for around an hour a day. Guess I could do more than that?! I don't have an office job which is good.
Being social - I mean, thanks Covid! Was relatively sociable before that.
Any more suggestions would be most welcome!
Also, does anyone know how APOE4 status affects fertility? We have been casually TTC since January so would be interested to know. Unless you have horror stories.... I don't want horror stories.
Also would be really nice to hear of "old" people who are APOE 4/4 and doing great!
Thanks everyone xox
My Heritage is the company which gave me the results for APOE 4/4. Should I do another test to confirm for sure? Or will this be accurate?
I also ran my raw data from My Heritage through Promethease yesterday which came up with a few other interesting bits of DNA. I think I found a few positives. If anyone knows anymore about them that would be greatly appreciated.
rs1799990 AG - resistance to vCJD, 4.6x reduced risk of Sporadic CJD and 0.87x reduced risk for LOAD.
rs10468017 CT - associated with higher HDL cholesterol
rs1061325 - two copies of 'farmer' CLTCL 1 gene variant - wasn't sure on this one because it seems to say that it means I am good at breaking down carbohydrates but also could potentially lead to insulin resistance?!
rs10936599 CC - this one just said 'longer telomeres, longer life?'
rs174537 TT - lower LDL-C and total cholesterol
rs4149268 AG - associated with higher HDL cholesterol
rs8164163 AG - associated with higher HDL cholesterol
rs261332 AG - associated with higher HDL cholesterol
rs4939883 CT - associated with higher HDL cholesterol
rs610932 AC - this was labelled as 'green' for good but didn't really say much. Just said it had some connection to AD.
rs2149954 AG - slight association with longer life (longevity)
In terms of prevention... I have been reading up lots on things which help...
Gain as high an education as possible in young age - I could read and write at 2 years old, was privately educated, gained two degrees and a professional qualification in my line of work. I would like to think I have that one covered!
Healthy diet / weight etc - I'm 5ft 3 and 8 stone 12ish so am a healthy weight. I eat freshly cooked meals at least 5 days of the week. I do like cake though... do I need to cut this out? Or would a slice or two a week matter if the rest of my diet is healthy?! Would love to know this.
Exercise - I walk my dog for around an hour a day. Guess I could do more than that?! I don't have an office job which is good.
Being social - I mean, thanks Covid! Was relatively sociable before that.
Any more suggestions would be most welcome!
Also, does anyone know how APOE4 status affects fertility? We have been casually TTC since January so would be interested to know. Unless you have horror stories.... I don't want horror stories.
Also would be really nice to hear of "old" people who are APOE 4/4 and doing great!
Thanks everyone xox