Stavia wrote:Fascinating. Bredesen postulated that the e4 evolved when we moved from an arboreal life to the savannah thus exposing us to cuts on our feet, carrion cos we were most likely scavangers, and fighting in competition. The gene is pro inflammatory thus helped kill pathogens. The negative effects would only kick in at later life which we would have been extremely unlikely to make. As we have evolved, e4 has slowly been selected out in favour of the newer e3. Evolution isnt an end game. Perhaps we were not well adapred for longevity as hunter gatherers. Perhaps the diet was optimal for reproduction only. We should not assume that the hunter gatherer lifestyle was well adapted for the e4 allele in terms of our modern purposes which is to prevent LOAD.. Remember the paradigm of the selfish gene.
Just saying. I guess we will never know
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