Poor choice of words, ApropoE4 I was trying to convey the idea that if Orbimed, the leading healthcare venture capital firm, believes this has the ability to work... I feel great confidence- as THEY clearly wouldn't make an unwise bet.
https://www.cbinsights.com/blog/healthc ... op-mosaic/
I just had a few more thoughts to share about our meet-up. I was thrilled to hear the depth of the science behind Dr. Bredesen's paper/MEND therapy which Stavia has briefly detailed here:
Basically the premise is that there is an interaction with apoe4 and pro inflammatory mediators such as RelA which tips the system towards a pro inflammatory state in which NFkB is dominant and SirT1 inadequate. This causes neurones to degenerate. Apoe4 does this by entering the nucleus and binding to 1800 gene promotors. They have grouped the effects into his programme's 36 "holes" which they are trying to plug thru their various modalities.
We will link that talk so that all will soon have the opportunity to see for themselves. Dr. Bredesen has now worked with 30+ patients some of which had either FDG-PET or amyloid scans indicative of AD- who've all shown reversal of cognitive decline. Many were previously high functioning physicians, lawyers, etc. who were able to return to work. I found it fascinating that symptoms returned when patients veered off of the protocol, but reversed upon resuming. This is not unlike what many report here. Dr. Bredesen is working to collect rigorous scientific evidence of the efficacy of the protocol; very difficult with a multifactorial, individualized approach. It will take time. John Walker, the CFO, of Muses Labs was also present to meet with us. They are working hard to make this more widely available. From everything I've learned, their approach is the best synthesis of strategies we've discussed here; providing a blueprint for our members until Pharma is ready.
The Buck truly rolled out the red carpet for us. Chef Rebecca Katz, author of "The Healthy Mind" cookbook provided a delicious lunch: greens, nuts, seeds, salmon, a variety of unsweetened teas and a yummy looking bite-sized dark chocolate dessert.
The entire experience was surreal. I wish you all could have been there; especially the old-timers. Our members were truly honored and celebrated. IMO, Dr. Bredesen is a great man because he was very comfortable shining a spotlight on our group's efforts. Many other scientists would have written us off as "crazies," instead he was fascinated by our journey and grandly acknowledged it. Dr. Bredesen deemed our assembly an historic moment. It felt like it.