Welcome Nikki2019!Nikki2019 wrote:Hi,
I read and quoted something I came across on the forum... please see below. Does this suggest that 3/4s even if they are age 40s will just have 20-25% risk? Or does it suggest that if you make it to age 60-75 with out any cognitive decline, that you are with in that stat for the next period of life? What about those of us that are late 40s and are 3/4s?NF52 wrote:So let me give you some very recent (2017) and very specific news from a large meta-analysis of population-based data on people with ApoE 3/4 ages 60-75..:
The Generation Study elected to disclose the following “lifetime” risks of [mild cognitive impairment] MCI or dementia to its potential participants: 30%–55% for individuals with APOE-e4/e4; 20%–25% for individuals with APOE-e3/e4 and -e2/e4 (with a note that risk might be lower for those with APOE-e2/e4).
APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts
Nikki2019 wrote:Hi, I read and quoted something I came across on the forum... please see below. Does this suggest that 3/4s even if they are age 40s will just have 20-25% risk? Or does it suggest that if you make it to age 60-75 with out any cognitive decline, that you are with in that stat for the next period of life? What about those of us that are late 40s and are 3/4s?
As Mark Twain once said, "There are lies, damned lies, and statistics!" That doesn't mean you have any cognitive decline; it means you're showing great cognitive reserve to find that article and identify the question!Nikki2019 wrote:...I have come across so many different stats...I have read that just one out of 50 are 4/4s and that risk of AD is 91% by age 68. I have also read that for 3/4s, its just 10-11% that have just one APOE4, and that by age 75 its a 50% chance of AD... In another journal,
http://www.jpreventionalzheimer.com/280 ... sease.html
I read that the stats. are a lot better. It also has a table which shows that the heterozygous group is a lot more common, at 24% of the general population. That same table shows a third row, which displays " percentage of AD population". I am completely lost on that section. The numbers listed there seem counter intuitive. It lists 4/4s as 10% and non carriers as 51%. I don't get it. Maybe I already have cognitive decline, ha! I better start building those reserves!
By the way, I am making a 2019 New Years Resolution list this year. I am going to have a hell of a time trying to cut out sugar!
Hi again Nikki!Nikki2019 wrote:Hi NF52,... I would like to find out what is going on with the folks that started on the trail. I can't wait so many years to find out the results... the suspense!
My father had no idea that AD would be so soon for him... Even though he is a 4/4, his 2 younger brothers still seem ok, but they haven't disclosed their APOE status. Neither of his parents had signs of dementia. One just lived until 67, but the other well into 80s. ... My father chained smoked many decades, and had an 11 day hospitalization for pneumonia with antibiotics and the works at age 64, then shortly after that it seems he had the cognitive decline.
Since you are doing well, I wonder how your parents did. Have you cut out sugar and how are you feeling ? How long have you been in the study? I also wonder if you did HRT, such as Stavia mentions in the primer. If you go to Spain, then I guess you'll do the shot for the study before or after the trip, assuming its a monthly shot. Feel free to ignore my questions if I am being too nosey! I wonder if you have the placebo or the real one. It is interesting and I tried to sign up for myself or my father, but I was in the wrong age group and my father has AD.
Welcome SusanH!SusanH wrote:I was recently tested for the new Navartis Study. I’m a E3/E4. “Your estimated risk of developing mild cognitive impairment or dementia related to Altzheimer’s through the age of 85 is between 20 and 25%.” Those were the exact words in statement. It’s okay. There’s lots we can do like telling the world the truth about statins Eating healthy and exercise (my downfall)
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