The Generation Study question
Posted: Tue Dec 18, 2018 6:23 pm
Hi,
I read and quoted something I came across on the forum... please see below. Does this suggest that 3/4s even if they are age 40s will just have 20-25% risk? Or does it suggest that if you make it to age 60-75 with out any cognitive decline, that you are with in that stat for the next period of life? What about those of us that are late 40s and are 3/4s?
So let me give you some very recent (2017) and very specific news from a large meta-analysis of population-based data on people with ApoE 3/4 ages 60-75, not your age (which I am guessing is 30's or early 40's):
The Generation Study elected to disclose the following “lifetime” risks of [mild cognitive impairment] MCI or dementia to its potential participants: 30%–55% for individuals with APOE-e4/e4; 20%–25% for individuals with APOE-e3/e4 and -e2/e4 (with a note that risk might be lower for those with APOE-e2/e4); and 10%–15% for individuals with APOE-e3/e3, -e3/e2, and -e2/e2 (with a note that risk might be lower for those with APOE-e2/e3 and -e2/e2).
APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts
I read and quoted something I came across on the forum... please see below. Does this suggest that 3/4s even if they are age 40s will just have 20-25% risk? Or does it suggest that if you make it to age 60-75 with out any cognitive decline, that you are with in that stat for the next period of life? What about those of us that are late 40s and are 3/4s?
So let me give you some very recent (2017) and very specific news from a large meta-analysis of population-based data on people with ApoE 3/4 ages 60-75, not your age (which I am guessing is 30's or early 40's):
The Generation Study elected to disclose the following “lifetime” risks of [mild cognitive impairment] MCI or dementia to its potential participants: 30%–55% for individuals with APOE-e4/e4; 20%–25% for individuals with APOE-e3/e4 and -e2/e4 (with a note that risk might be lower for those with APOE-e2/e4); and 10%–15% for individuals with APOE-e3/e3, -e3/e2, and -e2/e2 (with a note that risk might be lower for those with APOE-e2/e3 and -e2/e2).
APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts