A few months ago I read a review article on alcohol risks and Alzheimer's. I was particularly interested in studies that teased out differences, if any, related to genetics. I found it interesting that there were many research articles that indicated no increased risk of AD with light to moderate alcohol consumption, even in APOE4+. I chased down some of the cited studies for further reading to find out if those participants were just too young to have AD, or if they were tremendously fit, or if moderate drinking actually meant "rarely", or if they all lived on the island of Ikaria - but could see nothing that would indicate why in certain (many) studies, no increased risk was observed. However, my simmering concern about AD has compelled me to make many changes to my diet in the last few years, and one of those was to decrease alcohol consumption to two drinks, no more than once or twice a week. Like some of you have written, I believe I have given up a lot of my favorite foods, and I am reluctant to abstain completely from alcohol. However, I do believe that poor sleep is a contributing factor in AD, and alcohol is well-known to disrupt sleep, and it definitely does for me. Knowing that alcohol negatively affects my sleep keeps me from indulging as much as I would like, so I have given up on the idea that two glassed of red wine daily is healthy for me. Soon, I hope to know my APOE status, and that may help shape my thinking going forward, but is is unlikely that I will take up daily drinking, given the noticeable effects on my sleep. I am always interested in the insight and experiences of others looking for the right balance.
E3/E4, but still optimistic