I'm not sure where to post this so here it is.
I'm curious as to why diabetes is an underlying condition mentioned with covid-19. So I poked some words into google and now I need someone to explain what I found.
Here's a paper that seems to have a lot of words that I just don't understand. (Insulin Receptor-Mediated Stimulation Boosts T Cell Immunity during Inflammation and Infection; https://www.sciencedirect.com/science/a ... 3118305047). What is Insulin Receptor Signalling? I assume this has something to do with insulin but does it have anything to do with insulin resistance? The first hilight is "Insulin receptor signaling controls T cell proliferation and cytokine production." That's a curiosity because isn't over stimulation of cytokines the main reason people die from Covid-19? The cytokine storm?
I also found a paper about how obese mice had a more severe cytokine reaction to an infection than lean mice (Obesity Exacerbates the Cytokine Storm Elicited by Francisella tularensis Infection of Females and Is Associated with Increased Mortality; https://www.hindawi.com/journals/bmri/2018/3412732/). Something I could not quite understand (okay, mostly not at all) was "We conclude that increased basal leptin expression in obese individuals causes a persistent low-level inflammatory response making them more susceptible to F. tularensis infection and heightening the generation of the immunopathological cytokine storm." Is this saying obese mice are already activated to look for a fight, so to say, so when there is an infection it just lets the dam loose?
Or, if I'm just reading the wrong papers and you have a better, simple explanation of why diabetes is an underlying condition then please let me know.
Thanks, and take care.